TNF10_HUMAN » Tumor necrosis factor ligand superfamily member 10

TNF10_HUMAN » Tumor necrosis factor ligand superfamily member 10
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TNF10_HUMAN » Tumor necrosis factor ligand superfamily member 10 » Apo-2 ligand;Apo-2L; TNF-related apoptosis-inducing ligand;Protein TRAIL;
Hydrophobic Thickness 33.2 ± 6.0 Å
Tilt Angle 31 ± 0°
ΔGtransfer -22.2 kcal/mol
ΔGfold -15.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 15-42 (14-45)
Pathways

Apoptosis (KEGG)

Apoptosis (Reactome)

Cytokine-cytokine receptor interaction (KEGG)

Influenza A (KEGG)

Measles (KEGG)

Natural killer cell mediated cytotoxicity (KEGG)

PDB 4n90 (A/B/C=114-281), 1d0g (A/B/D=114-281), 1d2q (A/B=114-281), 1dg6 (A=91-281), 1d4v (B=119-281), 1du3 (D/E...=114-281)
OPM none
Complexes

TNF10:TR10B_HUMAN

Interactions

IEX1, Complex: TNF10:IEX1, PubMed

TNR1A, Complex: TR10A:RIPK1:TRAF2:TNF10:TNR1A:TNR6:TRADD:CFLAR

TNR1B, Complex: TNR1B:TNF10

TR10A, Complex: TNF10:TR10A, PubMed

TR10B, Complex: TNF10:TR10B, PDBID: 1d0g

TR10D, Complex: TR10D:TNF10, PubMed

Domains

AA: 152-280, PDBID: 1D0G, Subunit A, Seq Identity:100%, TNF(Tumour Necrosis Factor) family

UniProt annotation for TNF10_HUMAN » Tumor necrosis factor ligand superfamily member 10
FUNCTION: Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.

SUBUNIT: Homotrimer.

TISSUE SPECIFICITY: Widespread; most predominant in spleen, lung and prostate.

UniProt features for TNF10_HUMAN » Tumor necrosis factor ligand superfamily member 10
CHAIN 1 281 Tumor necrosis factor ligand superfamily member 10.
Amino Acid Sequence for TNF10_HUMAN » Tumor necrosis factor ligand superfamily member 10
MAMMEVQGGP SLGQTCVLIV IFTVLLQSLC VAVTYVYFTN ELKQMQDKYS KSGIACFLKE DDSYWDPNDE ESMNSPCWQV KWQLRQLVRK MILRTSEETI STVQEKQQNI SPLVRERGPQ RVAAHITGTR GRSNTLSSPN SKNEKALGRK INSWESSRSG HSFLSNLHLR NGELVIHEKG FYYIYSQTYF RFQEEIKENT KNDKQMVQYI YKYTSYPDPI LLMKSARNSC WSKDAEYGLY SIYQGGIFEL KENDRIFVSV TNEHLIDMDH EASFFGAFLV G