TN13B_HUMAN » Tumor necrosis factor ligand superfamily member 13B

TN13B_HUMAN » Tumor necrosis factor ligand superfamily member 13B
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TN13B_HUMAN » Tumor necrosis factor ligand superfamily member 13B » B lymphocyte stimulator;BLyS; B-cell-activating factor;BAFF;Dendritic cell-derived TNF-like molecule;TNF- and APOL-related leukocyte expressed ligand 1;TALL-1;
Hydrophobic Thickness 35.2 ± 1.8 Å
Tilt Angle 15 ± 8°
ΔGtransfer -22.5 kcal/mol
ΔGfold -15.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 45-69 (42-70)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

Intestinal immune network for IgA production (KEGG)

NF-kappa B signaling pathway (KEGG)

Rheumatoid arthritis (KEGG)

PDB 4v46 (138-285), 1oqd (142-285), 1oqe (142-285), 1kd7 (A/B...=133-285), 1kxg (A/B...=134-285), 1jh5 (A/B...=142-285), 1osg (A/B...=82-285), 3v56 (A/B...=82-285)
OPM none
Complexes

TN13B:TN13B_HUMAN

Interactions

A4, Complex: A4:TN13B, PubMed

TN13B, Complex: Homotrimer of tumor necrosis factor 13B, PDBID: 1OSG

TNF12, Complex: TN13B:TNF12

TNR17, Complex: TN13B:TNR17, PDBID: 1oqd, PubMed

TNR5, Complex: TN13B:TNR5, PubMed

TR13B, Complex: TR13B:TN13B, PubMed

TR13C, Complex: TN13B:TR13C, PDBID: 1oqe

TR13C, Complex: TR13C:TN13B, PubMed

Domains

AA: 169-284, PDBID: 1JH5, Subunit B, Seq Identity:100%, TNF(Tumour Necrosis Factor) family

UniProt annotation for TN13B_HUMAN » Tumor necrosis factor ligand superfamily member 13B
FUNCTION: Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.

FUNCTION: Isoform 2 seems to inhibit isoform 1 secretion and bioactivity.

FUNCTION: Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN- gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.

SUBUNIT: Homotrimer. Isoform 2 heteromultimerizes with isoform 1, probably limiting the amount of functional isoform 1 on the cell surface. Isoform 3 is unlikely form trimers or bind to BAFF receptors.

TISSUE SPECIFICITY: Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T- cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. Isoform 2 is expressed in many myeloid cell lines.

INDUCTION: Up-regulated by exposure to IFNG/IFN-gamma. Down- regulated by phorbol myristate acetate/ionomycin treatment.

UniProt features for TN13B_HUMAN » Tumor necrosis factor ligand superfamily member 13B
CHAIN 1 285 Tumor necrosis factor ligand superfamily member 13b, membrane form.
CHAIN 134 285 Tumor necrosis factor ligand superfamily member 13b, soluble form.
SITE 133 134 Cleavage.
DISULFID 232 245
Amino Acid Sequence for TN13B_HUMAN » Tumor necrosis factor ligand superfamily member 13B
MDDSTEREQS RLTSCLKKRE EMKLKECVSI LPRKESPSVR SSKDGKLLAA TLLLALLSCC LTVVSFYQVA ALQGDLASLR AELQGHHAEK LPAGAGAPKA GLEEAPAVTA GLKIFEPPAP GEGNSSQNSR NKRAVQGPEE TVTQDCLQLI ADSETPTIQK GSYTFVPWLL SFKRGSALEE KENKILVKET GYFFIYGQVL YTDKTYAMGH LIQRKKVHVF GDELSLVTLF RCIQNMPETL PNNSCYSAGI AKLEEGDELQ LAIPRENAQI SLDGDVTFFG ALKLL