TMX3_HUMAN » Protein disulfide-isomerase TMX3
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Topology in Endoplasmic reticulum membrane
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Topology in Endoplasmic reticulum membrane
 | lumenal side |
| cytoplasmic side |
- Type: 1. Transmembrane bitopic proteins (15 classes)
- Class: 1.13. Enzymes, isomerases (EC 5.) (4 superfamilies)
- Superfamily: 1.13.01. Protein disulfide isomerase (1 family) PF00085 (Pfam)
- Family: 1.13.01.01. Protein disulfide isomerase (6 proteins) IPR013766 (InterPro)
- Species: Homo sapiens (2303 proteins)
- Localization: Endoplasmic reticulum membrane (209 proteins)
| TMX3_HUMAN » Protein disulfide-isomerase TMX3 » Thioredoxin-related transmembrane protein 3;Thioredoxin domain-containing protein 10; | |
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| Hydrophobic Thickness | 28.8 ± 4.6 Å |
| Tilt Angle | 37 ± 1° |
| ΔGtransfer | -5.8 kcal/mol |
| Links to TMX3_HUMAN | UniProtKB, Pfam, iHOP, STRING, PharmGKB, HGNC, Wikipedia, Interpro |
| Topology | Out |
| Domains | AA: 27-129, PDBID: 2dj1, Subunit A, Seq Identity:41%, Thioredoxin |
| Transmembrane segments |
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| Segments: 374-399 |
| Annotation for TMX3_HUMAN » Protein disulfide-isomerase TMX3 |
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FUNCTION: Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. CATALYTIC ACTIVITY: Catalyzes the rearrangement of -S-S- bonds in proteins. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein. TISSUE SPECIFICITY: Widely expressed. Expressed in brain, testis, lung, skin, kidney, uterus, bone, stomach, liver, prostate, placenta, eye and muscle. INDUCTION: Not up-regulated by unfolded protein response (UPR). DOMAIN: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins (By similarity). -- Uniprot annotation-- |
| Comments on TMX3_HUMAN » Protein disulfide-isomerase TMX3 |
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SIGNAL 1 24 Potential. CHAIN 25 454 Protein disulfide-isomerase TMX3. DOMAIN 25 128 Thioredoxin. MOTIF 451 454 Di-lysine motif. DISULFID 53 56 Redox-active (By similarity). |
