TMM_ARATH » Protein TOO MANY MOUTHS

TMM_ARATH » Protein TOO MANY MOUTHS
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TMM_ARATH » Protein TOO MANY MOUTHS » Receptor-like protein 17;AtRLP17;
Hydrophobic Thickness 32.6 ± 4.0 Å
Tilt Angle 4 ± 5°
ΔGtransfer -20.6 kcal/mol
ΔGfold -10.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 474-495 (469-495)
Pathways none
PDB none
OPM none
Complexes none
Interactions

ERECT, Complex: ERECT:TMM

ERL1, Complex: ERL1:TMM

Domains

AA: 159-219, PDBID: 1ZIW, Subunit A, Seq Identity:39%, Leucine rich repeat

AA: 253-312, PDBID: 4J0M, Subunit A, Seq Identity:43%, Leucine rich repeat

AA: 314-363, PDBID: 4Z0C, Subunit D, Seq Identity:50%, Leucine rich repeat

UniProt annotation for TMM_ARATH » Protein TOO MANY MOUTHS
FUNCTION: Promotes cell fate progression in stomatal development. In leaves, needed to correctly orient spacing divisions, to limit the number of asymmetric divisions in neighbor cells, and to promote the asymmetric (amplifying) divisions of meristemoids. In stems, promotes the conversion of meristemoids into guard mother cells (GMC). Modulates probably the activity of the ligand- receptor pairs EPF2-ERECTA and EPF1-ERL1 via heterodimerization (PubMed).

SUBUNIT: Heterodimer with ERCTA or ERL1, but no homodimerization. Interacts with EPFL2, EPF5 but not with EPF1.

TISSUE SPECIFICITY: In epidermal cells of developing shoots and leaves, but not in roots. Expressed in the stomatal cell lineage in the developing epidermis.

DEVELOPMENTAL STAGE: Decreases as leaves matured and no expression in fully expanded leaves.

MISCELLANEOUS: TMM lacks an intracellular kinase domain and may participate in active signal transduction only through physical interaction with other proteins.

UniProt features for TMM_ARATH » Protein TOO MANY MOUTHS
SIGNAL 1 23 Potential.
CHAIN 24 496 Protein TOO MANY MOUTHS.
REPEAT 160 183 LRR 1.
REPEAT 184 205 LRR 2.
REPEAT 208 230 LRR 3.
REPEAT 231 250 LRR 4.
REPEAT 254 276 LRR 5.
REPEAT 278 298 LRR 6.
REPEAT 302 325 LRR 7.
REPEAT 328 351 LRR 8.
REPEAT 352 373 LRR 9.
REPEAT 376 397 LRR 10.
Amino Acid Sequence for TMM_ARATH » Protein TOO MANY MOUTHS
MARYEFFRQI FIVLSIVSPL VRSFTVITSD STAPSALIDG PQTGFTMTND GARTEPDEQD AVYDIMRATG NDWAAAIPDV CRGRWHGIEC MPDQDNVYHV VSLSFGALSD DTAFPTCDPQ RSYVSESLTR LKHLKALFFY RCLGRAPQRI PAFLGRLGSS LQTLVLRENG FLGPIPDELG NLTNLKVLDL HKNHLNGSIP LSFNRFSGLR SLDLSGNRLT GSIPGFVLPA LSVLDLNQNL LTGPVPPTLT SCGSLIKIDL SRNRVTGPIP ESINRLNQLV LLDLSYNRLS GPFPSSLQGL NSLQALMLKG NTKFSTTIPE NAFKGLKNLM ILVLSNTNIQ GSIPKSLTRL NSLRVLHLEG NNLTGEIPLE FRDVKHLSEL RLNDNSLTGP VPFERDTVWR MRRKLRLYNN AGLCVNRDSD LDDAFGSKSG STVRLCDAET SRPAPSGTVQ HLSREEDGAL PDGATDVSST SKSLGFSYLS AFFLVFPNFI FMLISS