TMM9B_HUMAN » Transmembrane protein 9B

TMM9B_HUMAN » Transmembrane protein 9B
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Topology in Lysosomal membrane
Topologylysosome lumenal side
cytoplasmic side
TMM9B_HUMAN » Transmembrane protein 9B »
Hydrophobic Thickness 35.6 ± 4.6 Å
Tilt Angle 11 ± 10°
ΔGtransfer -26.9 kcal/mol
ΔGfold -17.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 99-124 (94-125)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 54-197, TMEM9

UniProt annotation for TMM9B_HUMAN » Transmembrane protein 9B
FUNCTION: Enhances production of proinflammatory cytokines induced by TNF, IL1B, and TLR ligands. Has a role in TNF activation of both the NF-kappaB and MAPK pathways.
UniProt features for TMM9B_HUMAN » Transmembrane protein 9B
SIGNAL 1 33
CHAIN 34 198 Transmembrane protein 9B.
Amino Acid Sequence for TMM9B_HUMAN » Transmembrane protein 9B
MATLWGGLLR LGSLLSLSCL ALSVLLLAQL SDAAKNFEDV RCKCICPPYK ENSGHIYNKN ISQKDCDCLH VVEPMPVRGP DVEAYCLRCE CKYEERSSVT IKVTIIIYLS ILGLLLLYMV YLTLVEPILK RRLFGHAQLI QSDDDIGDHQ PFANAHDVLA RSRSRANVLN KVEYAQQRWK LQVQEQRKSV FDRHVVLS