TMM59_HUMAN » Transmembrane protein 59

TMM59_HUMAN » Transmembrane protein 59
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Topology in Endosome membrane
Topologyendosome lumenal side
cytoplasmic side
TMM59_HUMAN » Transmembrane protein 59 » Liver membrane-bound protein;
Hydrophobic Thickness 31.6 ± 6.6 Å
Tilt Angle 0 ± 2°
ΔGtransfer -35.8 kcal/mol
ΔGfold -17.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 239-260 (238-268)
Pathways none
PDB none
OPM none
Complexes none
Interactions

RYK, Complex: TMM59:RYK, PubMed

Domains

AA: 72-256, Brain specific membrane anchored protein

UniProt annotation for TMM59_HUMAN » Transmembrane protein 59
FUNCTION: Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding.

SUBUNIT: Interacts with ATG16L1.

DOMAIN: The ATG16L1-binding motif mediates interaction with ATG16L1 and promotes autophagy.

UniProt features for TMM59_HUMAN » Transmembrane protein 59
SIGNAL 1 35 Potential.
CHAIN 36 323 Transmembrane protein 59.
MOTIF 263 281 ATG16L1-binding motif.
Amino Acid Sequence for TMM59_HUMAN » Transmembrane protein 59
MAAPKGSLWV RTQLGLPPLL LLTMALAGGS GTASAEAFDS VLGDTASCHR ACQLTYPLHT YPKEEELYAC QRGCRLFSIC QFVDDGIDLN RTKLECESAC TEAYSQSDEQ YACHLGCQNQ LPFAELRQEQ LMSLMPKMHL LFPLTLVRSF WSDMMDSAQS FITSSWTFYL QADDGKIVIF QSKPEIQYAP HLEQEPTNLR ESSLSKMSYL QMRNSQAHRN FLEDGESDGF LRCLSLNSGW ILTTTLVLSV MVLLWICCAT VATAVEQYVP SEKLSIYGDL EFMNEQKLNR YPASSLVVVR SKTEDHEEAG PLPTKVNLAH SEI