TMEDA_YEAST » Endoplasmic reticulum vesicle protein 25

TMEDA_YEAST » Endoplasmic reticulum vesicle protein 25
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
TMEDA_YEAST » Endoplasmic reticulum vesicle protein 25 »
Hydrophobic Thickness 31.2 ± 2.8 Å
Tilt Angle 5 ± 7°
ΔGtransfer -17.5 kcal/mol
ΔGfold -11.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 178-198 (173-208)
Pathways none
PDB none
OPM 1m23 (RABIT)
Complexes

TMEDA:TMEDA_RABIT

Interactions

ALG5, Complex: ALG5:TMEDA, PubMed

CP51, Complex: CP51:TMEDA, PubMed

CUE1, Complex: TMEDA:CUE1

CWH41, Complex: TMEDA:CWH41

DPM1, Complex: TMEDA:DPM1

EMP24, Complex: TMEDA:EMP24, PubMed

EMP47, Complex: TMEDA:EMP47, PubMed

ERG2, Complex: ERG2:TMEDA

ERG5, Complex: TMEDA:ERG5, PubMed

ERP1, Complex: TMEDA:ERP1, PubMed

ERP2, Complex: TMEDA:ERP2, PubMed

ERP3, Complex: TMEDA:ERP3, PubMed

ERP4, Complex: TMEDA:ERP4, PubMed

ERP5, Complex: TMEDA:ERP5, PubMed

ERP6, Complex: TMEDA:ERP6, PubMed

GLRX2, Complex: GLRX2:TMEDA, PubMed

GPI16, Complex: TMEDA:GPI16, PubMed

GPI8, Complex: TMEDA:GPI8

GSF2, Complex: TMEDA:GSF2, PubMed

HLJ1, Complex: TMEDA:HLJ1

HOC1, Complex: TMEDA:HOC1

IRE1, Complex: TMEDA:IRE1

KTR3, Complex: TMEDA:KTR3, PubMed

MMM1, Complex: TMEDA:MMM1

MNN11, Complex: MNN11:TMEDA

MNN2, Complex: TMEDA:MNN2, PubMed

MSMO, Complex: MSMO:TMEDA, PubMed

NCB5R, Complex: NCB5R:TMEDA, PubMed

OST1, Complex: OST1:TMEDA, PubMed

OSTB, Complex: OSTB:TMEDA, PubMed

PMP2, Complex: TMEDA:PMP2, PubMed

SAC1, Complex: SAC1:TMEDA, PubMed

SCS2, Complex: TMEDA:SCS2

SEC11, Complex: TMEDA:SEC11, PubMed

SEC22, Complex: TMEDA:SEC22

SEC66, Complex: TMEDA:SEC66

SED4, Complex: TMEDA:SED4

SED5, Complex: SED5:TMEDA, PubMed

TLG2, Complex: TMEDA:TLG2

TMEDA, Complex: Homodimer of endoplasmic reticulum vesicle protein 25, PDBID: 1P23

UBX2, Complex: TMEDA:UBX2

YE053, Complex: TMEDA:YE053, PubMed

Domains

AA: 20-206, PDBID: 1M23, Subunit A, Seq Identity:24%, emp24/gp25L/p24 family/GOLD

UniProt annotation for TMEDA_YEAST » Endoplasmic reticulum vesicle protein 25
FUNCTION: Constituent of COPII-coated endoplasmic reticulum- derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. Possesses a C-terminal dilysine motif that interacts with COPI coat subunits. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum.

SUBUNIT: Associates with EMP24, ERP1 and ERP2.

MISCELLANEOUS: Present with 51700 molecules/cell in log phase SD medium.

UniProt features for TMEDA_YEAST » Endoplasmic reticulum vesicle protein 25
SIGNAL 1 20
CHAIN 21 211 Endoplasmic reticulum vesicle protein 25.
DOMAIN 33 121 GOLD.
Amino Acid Sequence for TMEDA_YEAST » Endoplasmic reticulum vesicle protein 25
MQVLQLWLTT LISLVVAVQG LHFDIAASTD PEQVCIRDFV TEGQLVVADI HSDGSVGDGQ KLNLFVRDSV GNEYRRKRDF AGDVRVAFTA PSSTAFDVCF ENQAQYRGRS LSRAIELDIE SGAEARDWNK ISANEKLKPI EVELRRVEEI TDEIVDELTY LKNREERLRD TNESTNRRVR NFSILVIIVL SSLGVWQVNY LKNYFKTKHI I