TMED9_HUMAN » Transmembrane emp24 domain-containing protein 9

TMED9_HUMAN » Transmembrane emp24 domain-containing protein 9
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
TMED9_HUMAN » Transmembrane emp24 domain-containing protein 9 » GMP25;Glycoprotein 25L2;p24 family protein alpha-2;p24alpha2; p25;
Hydrophobic Thickness 32.0 ± 1.4 Å
Tilt Angle 2 ± 0°
ΔGtransfer -38.2 kcal/mol
ΔGfold -12.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 203-225 (197-232)
Pathways none
PDB none
OPM none
Complexes none
Interactions

MA2A1, Complex: TMED9:MA2A1, PubMed

PTN2, Complex: PTN2:TMED9, PubMed

SC22B, Complex: TMED9:SC22B, PubMed

STX5, Complex: TMED9:STX5, PubMed

TMED1, Complex: TMED1:TMED9, PubMed

TMED2, Complex: TMED2:TMED9, PubMed

TMED7, Complex: TMED7:TMED9, PubMed

TMEDA, Complex: TMED9:TMEDA, PubMed

Domains

AA: 37-230, PDBID: 1M23, Subunit A, Seq Identity:21%, emp24/gp25L/p24 family/GOLD

UniProt annotation for TMED9_HUMAN » Transmembrane emp24 domain-containing protein 9
FUNCTION: Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer- dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB.

SUBUNIT: Monomer and homodimer in endoplasmic reticulum. Predominantly monomeric and to lesser extent homodimeric in endoplasmic reticulum-Golgi intermediate compartment and cis-Golgi network. Probably oligomerizes with other members of the EMP24/GP25L family such as TMED2, TMED7 and TMED10. Interacts with TMED5. Interacts (via C-terminus) with COPG1; the interaction involves dimeric TMED9. Interacts with PTPN2 and SPAST. Interacts with STX17; the interaction is direct.

UniProt features for TMED9_HUMAN » Transmembrane emp24 domain-containing protein 9
SIGNAL 1 37 By similarity.
CHAIN 38 235 Transmembrane emp24 domain-containing protein 9.
DOMAIN 47 145 GOLD.
COILED 154 184 Potential.
MOTIF 228 235 COPI vesicle coat-binding (Potential).
MOTIF 228 229 COPII vesicle coat-binding (Potential).
Amino Acid Sequence for TMED9_HUMAN » Transmembrane emp24 domain-containing protein 9
MAVELGVLLV RPRPGTGLGR VMRTLLLVLW LATRGSALYF HIGETEKKCF IEEIPDETMV IGNYRTQLYD KQREEYQPAT PGLGMFVEVK DPEDKVILAR QYGSEGRFTF TSHTPGEHQI CLHSNSTKFS LFAGGMLRVH LDIQVGEHAN DYAEIAAKDK LSELQLRVRQ LVEQVEQIQK EQNYQRWREE RFRQTSESTN QRVLWWSILQ TLILVAIGVW QMRHLKSFFE AKKLV