TMED7_HUMAN » Transmembrane emp24 domain-containing protein 7

TMED7_HUMAN » Transmembrane emp24 domain-containing protein 7
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
TMED7_HUMAN » Transmembrane emp24 domain-containing protein 7 » p24 family protein gamma-3;p24gamma3; p27;
Hydrophobic Thickness 23.6 ± 3.4 Å
Tilt Angle 1 ± 0°
ΔGtransfer -21.5 kcal/mol
ΔGfold -7.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 188-212 (188-215)
Pathways none
PDB none
OPM none
Complexes none
Interactions

IL1AP, Complex: IL1AP:TMED7, PubMed

IL1R1, Complex: IL1R1:TMED7, PubMed

TLR3, Complex: TLR3:TMED7, PubMed

TLR4, Complex: TLR4:TMED7, PubMed

TMED2, Complex: TMED7:TMED2, PubMed

TMED9, Complex: TMED7:TMED9, PubMed

TMEDA, Complex: TMED7:TMEDA, PubMed

TMPS3, Complex: TMED7:TMPS3, PubMed

Domains

AA: 36-213, PDBID: 1M23, Subunit A, Seq Identity:18%, emp24/gp25L/p24 family/GOLD

UniProt annotation for TMED7_HUMAN » Transmembrane emp24 domain-containing protein 7
FUNCTION: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post- translational modifications.

SUBUNIT: Predominantly monomeric and to lesser extent homodimeric in endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment and cis-Golgi network. Oligomerizes with other members of the EMP24/GP25L family such as TMED2, TMED9 and TMED10. Interacts (via C-terminus) with COPG1; the interaction involves dimeric TMED7.

UniProt features for TMED7_HUMAN » Transmembrane emp24 domain-containing protein 7
SIGNAL 1 34 Potential.
CHAIN 35 224 Transmembrane emp24 domain-containing protein 7.
DOMAIN 46 128 GOLD.
MOTIF 211 224 COPI vesicle coat-binding (Potential).
MOTIF 211 212 COPII vesicle coat-binding (Potential).
Amino Acid Sequence for TMED7_HUMAN » Transmembrane emp24 domain-containing protein 7
MPRPGSAQRW AAVAGRWGCR LLALLLLVPG PGGASEITFE LPDNAKQCFY EDIAQGTKCT LEFQVITGGH YDVDCRLEDP DGKVLYKEMK KQYDSFTFTA SKNGTYKFCF SNEFSTFTHK TVYFDFQVGE DPPLFPSENR VSALTQMESA CVSIHEALKS VIDYQTHFRL REAQGRSRAE DLNTRVAYWS VGEALILLVV SIGQVFLLKS FFSDKRTTTT RVGS