TMED5_HUMAN » Transmembrane emp24 domain-containing protein 5

TMED5_HUMAN » Transmembrane emp24 domain-containing protein 5
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
TMED5_HUMAN » Transmembrane emp24 domain-containing protein 5 » p24 family protein gamma-2;p24gamma2; p28;
Hydrophobic Thickness 31.2 ± 3.2 Å
Tilt Angle 37 ± 0°
ΔGtransfer -21.4 kcal/mol
ΔGfold -13.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 197-221 (197-227)
Pathways none
PDB none
OPM none
Complexes none
Interactions

LMAN1, Complex: TMED5:LMAN1

Domains

AA: 35-222, PDBID: 1M23, Subunit A, Seq Identity:16%, emp24/gp25L/p24 family/GOLD

UniProt annotation for TMED5_HUMAN » Transmembrane emp24 domain-containing protein 5
FUNCTION: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle- mediated retrograde transport.

SUBUNIT: Interacts with TMED9 and TMED10.

UniProt features for TMED5_HUMAN » Transmembrane emp24 domain-containing protein 5
SIGNAL 1 27 Potential.
CHAIN 28 229 Transmembrane emp24 domain-containing protein 5.
DOMAIN 45 126 GOLD.
Amino Acid Sequence for TMED5_HUMAN » Transmembrane emp24 domain-containing protein 5
MGDKIWLPFP VLLLAALPPV LLPGAAGFTP SLDSDFTFTL PAGQKECFYQ PMPLKASLEI EYQVLDGAGL DIDFHLASPE GKTLVFEQRK SDGVHTVETE VGDYMFCFDN TFSTISEKVI FFELILDNMG EQAQEQEDWK KYITGTDILD MKLEDILESI NSIKSRLSKS GHIQTLLRAF EARDRNIQES NFDRVNFWSM VNLVVMVVVS AIQVYMLKSL FEDKRKSRT