TMED4_HUMAN » Transmembrane emp24 domain-containing protein 4

TMED4_HUMAN » Transmembrane emp24 domain-containing protein 4
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
TMED4_HUMAN » Transmembrane emp24 domain-containing protein 4 » Endoplasmic reticulum stress-response protein 25;ERS25; GMP25iso;Putative NF-kappa-B-activating protein 156;p24 family protein alpha-3;p24alpha3;
Hydrophobic Thickness 34.4 ± 3.8 Å
Tilt Angle 0 ± 0°
ΔGtransfer -34.9 kcal/mol
ΔGfold -10.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 196-217 (188-224)
Pathways none
PDB none
OPM none
Complexes none
Interactions

IKIP, Complex: TMED4:IKIP, PubMed

SRPRB, Complex: TMED4:SRPRB, PubMed

TMED2, Complex: TMED2:TMED4, PubMed

Domains

AA: 29-222, PDBID: 1M23, Subunit A, Seq Identity:22%, emp24/gp25L/p24 family/GOLD

UniProt annotation for TMED4_HUMAN » Transmembrane emp24 domain-containing protein 4
FUNCTION: Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity).
UniProt features for TMED4_HUMAN » Transmembrane emp24 domain-containing protein 4
SIGNAL 1 29 Potential.
CHAIN 30 227 Transmembrane emp24 domain-containing protein 4.
DOMAIN 39 137 GOLD.
COILED 147 176 Potential.
MOTIF 220 227 COPI vesicle coat-binding (Potential).
MOTIF 220 221 COPII vesicle coat-binding (Potential).
Amino Acid Sequence for TMED4_HUMAN » Transmembrane emp24 domain-containing protein 4
MAGVGAGPLR AMGRQALLLL ALCATGAQGL YFHIGETEKR CFIEEIPDET MVIGNYRTQM WDKQKEVFLP STPGLGMHVE VKDPDGKVVL SRQYGSEGRF TFTSHTPGDH QICLHSNSTR MALFAGGKLR VHLDIQVGEH ANNYPEIAAK DKLTELQLRA RQLLDQVEQI QKEQDYQRYR EERFRLTSES TNQRVLWWSI AQTVILILTG IWQMRHLKSF FEAKKLV