TMED3_HUMAN » Transmembrane emp24 domain-containing protein 3

TMED3_HUMAN » Transmembrane emp24 domain-containing protein 3
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
TMED3_HUMAN » Transmembrane emp24 domain-containing protein 3 » Membrane protein p24B;p24 family protein gamma-4;p24gamma4; p26;
Hydrophobic Thickness 20.8 ± 0.6 Å
Tilt Angle 4 ± 1°
ΔGtransfer -19.0 kcal/mol
ΔGfold -8.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 186-206 (186-209)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 28-206, PDBID: 1M23, Subunit A, Seq Identity:19%, emp24/gp25L/p24 family/GOLD

UniProt annotation for TMED3_HUMAN » Transmembrane emp24 domain-containing protein 3
FUNCTION: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network.

SUBUNIT: Monomer in endoplasmic reticulum, endoplasmic reticulum- Golgi intermediate compartment and cis-Golgi network. Interacts (via C-terminus) with COPG1; the interaction involves dimeric TMED3; however, there are conflicting reports on the interaction. Interacts with GORASP1 and GORASP2 (By similarity).

UniProt features for TMED3_HUMAN » Transmembrane emp24 domain-containing protein 3
SIGNAL 1 23 Potential.
CHAIN 24 217 Transmembrane emp24 domain-containing protein 3.
DOMAIN 38 120 GOLD.
MOTIF 204 217 COPI vesicle coat-binding (Potential).
MOTIF 204 205 COPII vesicle coat-binding (Potential).
Amino Acid Sequence for TMED3_HUMAN » Transmembrane emp24 domain-containing protein 3
MGSTVPRSAS VLLLLLLLRR AEQPCGAELT FELPDNAKQC FHEEVEQGVK FSLDYQVITG GHYDVDCYVE DPQGNTIYRE TKKQYDSFTY RAEVKGVYQF CFSNEFSTFS HKTVYFDFQV GDEPPILPDM GNRVTALTQM ESACVTIHEA LKTVIDSQTH YRLREAQDRA RAEDLNSRVS YWSVGETIAL FVVSFSQVLL LKSFFTEKRP ISRAVHS