TMED1_HUMAN » Transmembrane emp24 domain-containing protein 1

TMED1_HUMAN » Transmembrane emp24 domain-containing protein 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TMED1_HUMAN » Transmembrane emp24 domain-containing protein 1 » Interleukin-1 receptor-like 1 ligand;Putative T1/ST2 receptor-binding protein;p24 family protein gamma-1;Tp24; p24gamma1;
Hydrophobic Thickness 27.6 ± 2.4 Å
Tilt Angle 2 ± 1°
ΔGtransfer -31.4 kcal/mol
ΔGfold -13.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 195-219 (195-222)
Pathways none
PDB none
OPM none
Complexes none
Interactions

ILRL1, Complex: ILRL1:TMED1, PubMed

TMED9, Complex: TMED1:TMED9, PubMed

Domains

AA: 33-220, PDBID: 1M23, Subunit A, Seq Identity:15%, emp24/gp25L/p24 family/GOLD

UniProt annotation for TMED1_HUMAN » Transmembrane emp24 domain-containing protein 1
FUNCTION: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side.

SUBUNIT: Homodimer in endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment and cis-Golgi network. May interact with IL1RL1.

TISSUE SPECIFICITY: Widely expressed.

MISCELLANEOUS: Found only in very low concentrations in the endoplasmic reticulum, Golgi apparatus and endoplasmic reticulum- Golgi intermediate compartment compared to other members of the EMP24/GP25L family.

UniProt features for TMED1_HUMAN » Transmembrane emp24 domain-containing protein 1
SIGNAL 1 23
CHAIN 24 227 Transmembrane emp24 domain-containing protein 1.
DOMAIN 43 125 GOLD.
COILED 145 170 Potential.
MOTIF 218 227 COPI vesicle coat-binding (Potential).
MOTIF 218 219 COPII vesicle coat-binding (Potential).
Amino Acid Sequence for TMED1_HUMAN » Transmembrane emp24 domain-containing protein 1
MMAAGAALAL ALWLLMPPVE VGGAGPPPIQ DGEFTFLLPA GRKQCFYQSA PANASLETEY QVIGGAGLDV DFTLESPQGV LLVSESRKAD GVHTVEPTEA GDYKLCFDNS FSTISEKLVF FELIFDSLQD DEEVEGWAEA VEPEEMLDVK MEDIKESIET MRTRLERSIQ MLTLLRAFEA RDRNLQEGNL ERVNFWSAVN VAVLLLVAVL QVCTLKRFFQ DKRPVPT