TM59L_HUMAN » Transmembrane protein 59-like

TM59L_HUMAN » Transmembrane protein 59-like
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Topology in Golgi apparatus membrane
TopologyGolgi lumenal side
cytoplasmic side
TM59L_HUMAN » Transmembrane protein 59-like » Brain-specific membrane-anchored protein;
Hydrophobic Thickness 27.6 ± 2.0 Å
Tilt Angle 9 ± 8°
ΔGtransfer -35.2 kcal/mol
ΔGfold -13.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 268-289 (266-292)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 79-284, Brain specific membrane anchored protein

UniProt annotation for TM59L_HUMAN » Transmembrane protein 59-like
FUNCTION: Modulates the O-glycosylation and complex N- glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding.

TISSUE SPECIFICITY: Expressed preferentially at high level in the brain.

UniProt features for TM59L_HUMAN » Transmembrane protein 59-like
SIGNAL 1 24 Potential.
CHAIN 25 342 Transmembrane protein 59-like.
MOTIF 340 342 Microbody targeting signal (Potential).
Amino Acid Sequence for TM59L_HUMAN » Transmembrane protein 59-like
MAAVALMPPP LLLLLLLASP PAASAPSARD PFAPQLGDTQ NCQLRCRDRD LGPQPSQAGL EGASESPYDR AVLISACERG CRLFSICRFV ARSSKPNATQ TECEAACVEA YVKEAEQQAC SHGCWSQPAE PEPEQKRKVL EAPSGALSLL DLFSTLCNDL VNSAQGFVSS TWTYYLQTDN GKVVVFQTQP IVESLGFQGG RLQRVEVTWR GSHPEALEVH VDPVGPLDKV RKAKIRVKTS SKAKVESEEP QDNDFLSCMS RRSGLPRWIL ACCLFLSVLV MLWLSCSTLV TAPGQHLKFQ PLTLEQHKGF MMEPDWPLYP PPSHACEDSL PPYKLKLDLT KL