TM219_HUMAN » Insulin-like growth factor-binding protein 3 receptor

TM219_HUMAN » Insulin-like growth factor-binding protein 3 receptor
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TM219_HUMAN » Insulin-like growth factor-binding protein 3 receptor » IGFBP-3R; Transmembrane protein 219;
Hydrophobic Thickness 30.4 ± 3.5 Å
Tilt Angle 2 ± 3°
ΔGtransfer -20.2 kcal/mol
ΔGfold -12.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 205-225 (203-225)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 10-85, Transmembrane 219

AA: 81-176, Transmembrane 219

UniProt annotation for TM219_HUMAN » Insulin-like growth factor-binding protein 3 receptor
FUNCTION: Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding.

SUBUNIT: Interacts with IGFBP3. Interacts with CASP8.

TISSUE SPECIFICITY: Widely expressed in normal tissues but suppressed in prostate and breast tumor.

UniProt features for TM219_HUMAN » Insulin-like growth factor-binding protein 3 receptor
SIGNAL 1 38 Potential.
CHAIN 39 240 Insulin-like growth factor-binding protein 3 receptor.
Amino Acid Sequence for TM219_HUMAN » Insulin-like growth factor-binding protein 3 receptor
MGNCQAGHNL HLCLAHHPPL VCATLILLLL GLSGLGLGSF LLTHRTGLRS PDIPQDWVSF LRSFGQLTLC PRNGTVTGKW RGSHVVGLLT TLNFGDGPDR NKTRTFQATV LGSQMGLKGS SAGQLVLITA RVTTERTAGT CLYFSAVPGI LPSSQPPISC SEEGAGNATL SPRMGEECVS VWSHEGLVLT KLLTSEELAL CGSRLLVLGS FLLLFCGLLC CVTAMCFHPR RESHWSRTRL