TLR9_HUMAN » Toll-like receptor 9

TLR9_HUMAN » Toll-like receptor 9
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Topology in Endosome membrane
Topologyendosome lumenal side
cytoplasmic side
TLR9_HUMAN » Toll-like receptor 9 »
Hydrophobic Thickness 31.6 ± 3.4 Å
Tilt Angle 3 ± 0°
ΔGtransfer -33.4 kcal/mol
ΔGfold -10.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome, HMDB
Topology Out
TM Segments 816-838 (816-838)
Pathways

African trypanosomiasis (KEGG)

Chagas disease (KEGG)

Herpes simplex infection (KEGG)

Immune System (Reactome)

Malaria (KEGG)

Measles (KEGG)

Signal Transduction (Reactome)

Toll-like receptor signaling pathway (KEGG)

Tuberculosis (KEGG)

PDB none
OPM none
Complexes none
Interactions

CLGN, Complex: CLGN:TLR9, PubMed

CLGN, Complex: UGGG1:PALD:TLR9:UN93B:CLGN:S11IP:TRAF3:TOLIP, PubMed

PLS1, Complex: TLR9:PLS1, PubMed

RAGE, Complex: TLR9:RAGE, PubMed

SIGIR, Complex: TLR9:SIGIR, PubMed

TLR1, Complex: TLR9:TLR1, PubMed

TLR8, Complex: TLR9:TLR8, PubMed

Domains

AA: 51-98, PDBID: 3REZ, Subunit B, Seq Identity:51%, Leucine rich repeat

AA: 123-137, PDBID: 3WPB, Subunit A, Seq Identity:81%, Leucine Rich repeat

AA: 245-283, PDBID: 3WPF, Subunit A, Seq Identity:59%, Leucine Rich Repeat

AA: 286-345, PDBID: 1OZN, Subunit A, Seq Identity:41%, Leucine rich repeat

AA: 701-762, PDBID: 3WPE, Subunit A, Seq Identity:75%, Leucine rich repeat

AA: 870-1029, PDBID: 1FYW, Subunit A, Seq Identity:31%, TIR domain

UniProt annotation for TLR9_HUMAN » Toll-like receptor 9
FUNCTION: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection.

SUBUNIT: Interacts with MYD88 via their respective TIR domains (By similarity). Interacts (via transmembrane domain) with UNC93B1 (By similarity). Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses (By similarity). Interacts with BTK. Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum.

TISSUE SPECIFICITY: Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre- dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver.

UniProt features for TLR9_HUMAN » Toll-like receptor 9
SIGNAL 1 25 Potential.
CHAIN 26 1032 Toll-like receptor 9.
REPEAT 62 85 LRR 1.
REPEAT 87 110 LRR 2.
REPEAT 122 147 LRR 3.
REPEAT 150 166 LRR 4.
REPEAT 167 190 LRR 5.
REPEAT 198 221 LRR 6.
REPEAT 223 242 LRR 7.
REPEAT 243 268 LRR 8.
REPEAT 283 306 LRR 9.
REPEAT 308 332 LRR 10.
REPEAT 333 356 LRR 11.
REPEAT 363 386 LRR 12.
REPEAT 390 413 LRR 13.
REPEAT 415 440 LRR 14.
REPEAT 470 494 LRR 15.
REPEAT 496 519 LRR 16.
REPEAT 520 543 LRR 17.
REPEAT 545 572 LRR 18.
REPEAT 574 598 LRR 19.
REPEAT 600 622 LRR 20.
REPEAT 627 650 LRR 21.
REPEAT 652 675 LRR 22.
REPEAT 676 699 LRR 23.
REPEAT 701 723 LRR 24.
REPEAT 724 747 LRR 25.
REPEAT 749 772 LRR 26.
DOMAIN 868 1016 TIR.
Amino Acid Sequence for TLR9_HUMAN » Toll-like receptor 9
MGFCRSALHP LSLLVQAIML AMTLALGTLP AFLPCELQPH GLVNCNWLFL KSVPHFSMAA PRGNVTSLSL SSNRIHHLHD SDFAHLPSLR HLNLKWNCPP VGLSPMHFPC HMTIEPSTFL AVPTLEELNL SYNNIMTVPA LPKSLISLSL SHTNILMLDS ASLAGLHALR FLFMDGNCYY KNPCRQALEV APGALLGLGN LTHLSLKYNN LTVVPRNLPS SLEYLLLSYN RIVKLAPEDL ANLTALRVLD VGGNCRRCDH APNPCMECPR HFPQLHPDTF SHLSRLEGLV LKDSSLSWLN ASWFRGLGNL RVLDLSENFL YKCITKTKAF QGLTQLRKLN LSFNYQKRVS FAHLSLAPSF GSLVALKELD MHGIFFRSLD ETTLRPLARL PMLQTLRLQM NFINQAQLGI FRAFPGLRYV DLSDNRISGA SELTATMGEA DGGEKVWLQP GDLAPAPVDT PSSEDFRPNC STLNFTLDLS RNNLVTVQPE MFAQLSHLQC LRLSHNCISQ AVNGSQFLPL TGLQVLDLSH NKLDLYHEHS FTELPRLEAL DLSYNSQPFG MQGVGHNFSF VAHLRTLRHL SLAHNNIHSQ VSQQLCSTSL RALDFSGNAL GHMWAEGDLY LHFFQGLSGL IWLDLSQNRL HTLLPQTLRN LPKSLQVLRL RDNYLAFFKW WSLHFLPKLE VLDLAGNQLK ALTNGSLPAG TRLRRLDVSC NSISFVAPGF FSKAKELREL NLSANALKTV DHSWFGPLAS ALQILDVSAN PLHCACGAAF MDFLLEVQAA VPGLPSRVKC GSPGQLQGLS IFAQDLRLCL DEALSWDCFA LSLLAVALGL GVPMLHHLCG WDLWYCFHLC LAWLPWRGRQ SGRDEDALPY DAFVVFDKTQ SAVADWVYNE LRGQLEECRG RWALRLCLEE RDWLPGKTLF ENLWASVYGS RKTLFVLAHT DRVSGLLRAS FLLAQQRLLE DRKDVVVLVI LSPDGRRSRY VRLRQRLCRQ SVLLWPHQPS GQRSFWAQLG MALTRDNHHF YNRNFCQGPT AE