TLR8_HUMAN » Toll-like receptor 8

TLR8_HUMAN » Toll-like receptor 8
Magnify TLR8_HUMAN » Toll-like receptor 8Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Endosome membrane
Topologyendosome lumenal side
cytoplasmic side
TLR8_HUMAN » Toll-like receptor 8 »
Hydrophobic Thickness 41.2 ± 1.2 Å
Tilt Angle 1 ± 0°
ΔGtransfer -51.6 kcal/mol
ΔGfold -26.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 825-853 (825-854)
Pathways

Immune System (Reactome)

Toll-like receptor signaling pathway (KEGG)

PDB 4r07 (A/B/C/D=27-827), 3w3l (A/B/C/D=27-827), 4r09 (A/B/C/D=27-827), 4r08 (A/B/C/D=27-827), 4qc0 (A/B=27-827), 4qbz (A/B=27-827), 3w3n (A/B=27-827), 3w3k (A/B=27-827), 3w3j (A/B=27-827), 3w3g (A/B=27-827), 3wn4 (A=27-827), 3w3m (A=27-827), 4r0a (A=27-827)
OPM none
Complexes

TLR8:TLR8_HUMAN

Interactions

TLR7, Complex: TLR7:TLR8, PubMed

TLR8, Complex: Homodimer of toll-like receptor 8, PDBID: 3W3N

TLR9, Complex: TLR9:TLR8, PubMed

Domains

AA: 65-86, PDBID: 3W3G, Subunit B, Seq Identity:100%, Leucine Rich Repeat

AA: 276-323, PDBID: 3W3G, Subunit B, Seq Identity:100%, Leucine rich repeat

AA: 639-700, PDBID: 3W3G, Subunit B, Seq Identity:100%, Leucine rich repeat

AA: 712-774, PDBID: 3W3G, Subunit B, Seq Identity:100%, Leucine rich repeat

AA: 879-1039, PDBID: 1FYW, Subunit A, Seq Identity:36%, TIR domain

UniProt annotation for TLR8_HUMAN » Toll-like receptor 8
FUNCTION: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

SUBUNIT: Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1 (By similarity). Homodimer. Interacts with BTK.

TISSUE SPECIFICITY: Detected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+ immature dendritic cells.

UniProt features for TLR8_HUMAN » Toll-like receptor 8
SIGNAL 1 26 Potential.
CHAIN 27 1041 Toll-like receptor 8.
REPEAT 126 147 LRR 1.
REPEAT 148 168 LRR 2.
REPEAT 171 193 LRR 3.
REPEAT 202 223 LRR 4.
REPEAT 224 244 LRR 5.
REPEAT 247 268 LRR 6.
REPEAT 288 309 LRR 7.
REPEAT 312 334 LRR 8.
REPEAT 338 360 LRR 9.
REPEAT 368 389 LRR 10.
REPEAT 395 416 LRR 11.
REPEAT 419 440 LRR 12.
REPEAT 482 503 LRR 13.
REPEAT 506 527 LRR 14.
REPEAT 531 551 LRR 15.
REPEAT 555 577 LRR 16.
REPEAT 585 606 LRR 17.
REPEAT 609 630 LRR 18.
REPEAT 640 661 LRR 19.
REPEAT 665 685 LRR 20.
REPEAT 689 710 LRR 21.
REPEAT 713 734 LRR 22.
REPEAT 737 758 LRR 23.
DOMAIN 772 824 LRRCT.
DOMAIN 878 1025 TIR.
Amino Acid Sequence for TLR8_HUMAN » Toll-like receptor 8
MENMFLQSSM LTCIFLLISG SCELCAEENF SRSYPCDEKK QNDSVIAECS NRRLQEVPQT VGKYVTELDL SDNFITHITN ESFQGLQNLT KINLNHNPNV QHQNGNPGIQ SNGLNITDGA FLNLKNLREL LLEDNQLPQI PSGLPESLTE LSLIQNNIYN ITKEGISRLI NLKNLYLAWN CYFNKVCEKT NIEDGVFETL TNLELLSLSF NSLSHVPPKL PSSLRKLFLS NTQIKYISEE DFKGLINLTL LDLSGNCPRC FNAPFPCVPC DGGASINIDR FAFQNLTQLR YLNLSSTSLR KINAAWFKNM PHLKVLDLEF NYLVGEIASG AFLTMLPRLE ILDLSFNYIK GSYPQHINIS RNFSKLLSLR ALHLRGYVFQ ELREDDFQPL MQLPNLSTIN LGINFIKQID FKLFQNFSNL EIIYLSENRI SPLVKDTRQS YANSSSFQRH IRKRRSTDFE FDPHSNFYHF TRPLIKPQCA AYGKALDLSL NSIFFIGPNQ FENLPDIACL NLSANSNAQV LSGTEFSAIP HVKYLDLTNN RLDFDNASAL TELSDLEVLD LSYNSHYFRI AGVTHHLEFI QNFTNLKVLN LSHNNIYTLT DKYNLESKSL VELVFSGNRL DILWNDDDNR YISIFKGLKN LTRLDLSLNR LKHIPNEAFL NLPASLTELH INDNMLKFFN WTLLQQFPRL ELLDLRGNKL LFLTDSLSDF TSSLRTLLLS HNRISHLPSG FLSEVSSLKH LDLSSNLLKT INKSALETKT TTKLSMLELH GNPFECTCDI GDFRRWMDEH LNVKIPRLVD VICASPGDQR GKSIVSLELT TCVSDVTAVI LFFFTFFITT MVMLAALAHH LFYWDVWFIY NVCLAKVKGY RSLSTSQTFY DAYISYDTKD ASVTDWVINE LRYHLEESRD KNVLLCLEER DWDPGLAIID NLMQSINQSK KTVFVLTKKY AKSWNFKTAF YLALQRLMDE NMDVIIFILL EPVLQHSQYL RLRQRICKSS ILQWPDNPKA EGLFWQTLRN VVLTENDSRY NNMYVDSIKQ Y