TLR7_HUMAN » Toll-like receptor 7

TLR7_HUMAN » Toll-like receptor 7
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Topology in Endosome membrane
Topologyendosome lumenal side
cytoplasmic side
TLR7_HUMAN » Toll-like receptor 7 »
Hydrophobic Thickness 38.8 ± 1.2 Å
Tilt Angle 0 ± 1°
ΔGtransfer -40.2 kcal/mol
ΔGfold -14.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 837-862 (837-865)
Pathways

Immune System (Reactome)

Influenza A (KEGG)

Measles (KEGG)

Toll-like receptor signaling pathway (KEGG)

PDB none
OPM none
Complexes none
Interactions

GRM1A, Complex: GRM1A:TLR7, PubMed

TLR8, Complex: TLR7:TLR8, PubMed

Domains

AA: 496-554, PDBID: 3WPE, Subunit A, Seq Identity:54%, Leucine rich repeat

AA: 700-744, PDBID: 4M7E, Subunit C, Seq Identity:28%, Leucine Rich Repeat

AA: 890-1048, PDBID: 1FYW, Subunit A, Seq Identity:30%, TIR domain

UniProt annotation for TLR7_HUMAN » Toll-like receptor 7
FUNCTION: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).

SUBUNIT: Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1 (By similarity).

TISSUE SPECIFICITY: Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.

UniProt features for TLR7_HUMAN » Toll-like receptor 7
SIGNAL 1 26 Potential.
CHAIN 27 1049 Toll-like receptor 7.
REPEAT 43 64 LRR 1.
REPEAT 65 87 LRR 2.
REPEAT 110 126 LRR 3.
REPEAT 127 149 LRR 4.
REPEAT 151 170 LRR 5.
REPEAT 171 195 LRR 6.
REPEAT 203 226 LRR 7.
REPEAT 228 247 LRR 8.
REPEAT 248 275 LRR 9.
REPEAT 289 312 LRR 10.
REPEAT 314 337 LRR 11.
REPEAT 339 368 LRR 12.
REPEAT 369 392 LRR 13.
REPEAT 396 419 LRR 14.
REPEAT 421 443 LRR 15.
REPEAT 492 515 LRR 16.
REPEAT 516 540 LRR 17.
REPEAT 541 564 LRR 18.
REPEAT 566 588 LRR 19.
REPEAT 595 618 LRR 20.
REPEAT 619 644 LRR 21.
REPEAT 649 672 LRR 22.
REPEAT 674 697 LRR 23.
REPEAT 698 721 LRR 24.
REPEAT 723 745 LRR 25.
REPEAT 746 769 LRR 26.
REPEAT 772 795 LRR 27.
DOMAIN 889 1036 TIR.
Amino Acid Sequence for TLR7_HUMAN » Toll-like receptor 7
MVFPMWTLKR QILILFNIIL ISKLLGARWF PKTLPCDVTL DVPKNHVIVD CTDKHLTEIP GGIPTNTTNL TLTINHIPDI SPASFHRLDH LVEIDFRCNC VPIPLGSKNN MCIKRLQIKP RSFSGLTYLK SLYLDGNQLL EIPQGLPPSL QLLSLEANNI FSIRKENLTE LANIEILYLG QNCYYRNPCY VSYSIEKDAF LNLTKLKVLS LKDNNVTAVP TVLPSTLTEL YLYNNMIAKI QEDDFNNLNQ LQILDLSGNC PRCYNAPFPC APCKNNSPLQ IPVNAFDALT ELKVLRLHSN SLQHVPPRWF KNINKLQELD LSQNFLAKEI GDAKFLHFLP SLIQLDLSFN FELQVYRASM NLSQAFSSLK SLKILRIRGY VFKELKSFNL SPLHNLQNLE VLDLGTNFIK IANLSMFKQF KRLKVIDLSV NKISPSGDSS EVGFCSNART SVESYEPQVL EQLHYFRYDK YARSCRFKNK EASFMSVNES CYKYGQTLDL SKNSIFFVKS SDFQHLSFLK CLNLSGNLIS QTLNGSEFQP LAELRYLDFS NNRLDLLHST AFEELHKLEV LDISSNSHYF QSEGITHMLN FTKNLKVLQK LMMNDNDISS STSRTMESES LRTLEFRGNH LDVLWREGDN RYLQLFKNLL KLEELDISKN SLSFLPSGVF DGMPPNLKNL SLAKNGLKSF SWKKLQCLKN LETLDLSHNQ LTTVPERLSN CSRSLKNLIL KNNQIRSLTK YFLQDAFQLR YLDLSSNKIQ MIQKTSFPEN VLNNLKMLLL HHNRFLCTCD AVWFVWWVNH TEVTIPYLAT DVTCVGPGAH KGQSVISLDL YTCELDLTNL ILFSLSISVS LFLMVMMTAS HLYFWDVWYI YHFCKAKIKG YQRLISPDCC YDAFIVYDTK DPAVTEWVLA ELVAKLEDPR EKHFNLCLEE RDWLPGQPVL ENLSQSIQLS KKTVFVMTDK YAKTENFKIA FYLSHQRLMD EKVDVIILIF LEKPFQKSKF LQLRKRLCGS SVLEWPTNPQ AHPYFWQCLK NALATDNHVA YSQVFKETV