TLR6_HUMAN » Toll-like receptor 6

TLR6_HUMAN » Toll-like receptor 6
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TLR6_HUMAN » Toll-like receptor 6 »
Hydrophobic Thickness 42.0 ± 2.8 Å
Tilt Angle 0 ± 2°
ΔGtransfer -44.8 kcal/mol
ΔGfold -21.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 580-611 (579-611)
Pathways

Chagas disease (KEGG)

Immune System (Reactome)

Phagosome (KEGG)

Toll-like receptor signaling pathway (KEGG)

Tuberculosis (KEGG)

PDB 4om7 (A/B=640-796)
OPM none
Complexes

TLR6:TLR2:Q4G1L3:Q4G1L2_MOUSE

TLR6:TLR6_HUMAN

Interactions

TLR2, Complex: TLR2:TLR6, PDBID: 3a79, PubMed

TLR4, Complex: TLR6:TLR4:CD36, PubMed

TLR6, Complex: Homodimer of toll-like receptor 6, PDBID: 4OM7

Domains

AA: 76-133, PDBID: 2Z7X, Subunit B, Seq Identity:70%, Leucine rich repeat

AA: 450-507, PDBID: 2Z7X, Subunit B, Seq Identity:98%, Leucine rich repeat

AA: 558-583, PDBID: 4V2C, Subunit C, Seq Identity:36%, Leucine rich repeat C-terminal domain

AA: 641-796, PDBID: 4OM7, Subunit A, Seq Identity:100%, TIR domain

UniProt annotation for TLR6_HUMAN » Toll-like receptor 6
FUNCTION: Participates in the innate immune response to Gram- positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage- activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.

SUBUNIT: Binds MYD88 via their respective TIR domains. Heterodimer with TLR2 via their respective extracellular domains (By similarity). Interacts with CD36, following CD36 stimulation by oxLDL or amyloid-beta 42, and forms a heterodimer with TLR4. The trimeric complex is internalized and triggers inflammatory response. LYN kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation.

TISSUE SPECIFICITY: Detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.

UniProt features for TLR6_HUMAN » Toll-like receptor 6
SIGNAL 1 31 Potential.
CHAIN 32 796 Toll-like receptor 6.
REPEAT 54 77 LRR 1.
REPEAT 78 101 LRR 2.
REPEAT 102 122 LRR 3.
REPEAT 123 147 LRR 4.
REPEAT 148 168 LRR 5.
REPEAT 169 196 LRR 6.
REPEAT 197 219 LRR 7.
REPEAT 220 250 LRR 8.
REPEAT 251 277 LRR 9.
REPEAT 278 303 LRR 10.
REPEAT 304 330 LRR 11.
REPEAT 331 354 LRR 12.
REPEAT 355 378 LRR 13.
REPEAT 379 404 LRR 14.
REPEAT 405 429 LRR 15.
REPEAT 430 450 LRR 16.
REPEAT 451 474 LRR 17.
REPEAT 475 496 LRR 18.
REPEAT 497 520 LRR 19.
DOMAIN 521 575 LRRCT.
DOMAIN 640 784 TIR.
DISULFID 117 139 By similarity.
DISULFID 235 265 By similarity.
DISULFID 348 373 By similarity.
DISULFID 424 447 By similarity.
Amino Acid Sequence for TLR6_HUMAN » Toll-like receptor 6
MTKDKEPIVK SFHFVCLMII IVGTRIQFSD GNEFAVDKSK RGLIHVPKDL PLKTKVLDMS QNYIAELQVS DMSFLSELTV LRLSHNRIQL LDLSVFKFNQ DLEYLDLSHN QLQKISCHPI VSFRHLDLSF NDFKALPICK EFGNLSQLNF LGLSAMKLQK LDLLPIAHLH LSYILLDLRN YYIKENETES LQILNAKTLH LVFHPTSLFA IQVNISVNTL GCLQLTNIKL NDDNCQVFIK FLSELTRGPT LLNFTLNHIE TTWKCLVRVF QFLWPKPVEY LNIYNLTIIE SIREEDFTYS KTTLKALTIE HITNQVFLFS QTALYTVFSE MNIMMLTISD TPFIHMLCPH APSTFKFLNF TQNVFTDSIF EKCSTLVKLE TLILQKNGLK DLFKVGLMTK DMPSLEILDV SWNSLESGRH KENCTWVESI VVLNLSSNML TDSVFRCLPP RIKVLDLHSN KIKSVPKQVV KLEALQELNV AFNSLTDLPG CGSFSSLSVL IIDHNSVSHP SADFFQSCQK MRSIKAGDNP FQCTCELREF VKNIDQVSSE VLEGWPDSYK CDYPESYRGS PLKDFHMSEL SCNITLLIVT IGATMLVLAV TVTSLCIYLD LPWYLRMVCQ WTQTRRRARN IPLEELQRNL QFHAFISYSE HDSAWVKSEL VPYLEKEDIQ ICLHERNFVP GKSIVENIIN CIEKSYKSIF VLSPNFVQSE WCHYELYFAH HNLFHEGSNN LILILLEPIP QNSIPNKYHK LKALMTQRTY LQWPKEKSKR GLFWANIRAA FNMKLTLVTE NNDVKS