TLR1_HUMAN » Toll-like receptor 1

TLR1_HUMAN » Toll-like receptor 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TLR1_HUMAN » Toll-like receptor 1 » Toll/interleukin-1 receptor-like protein;TIL;
Hydrophobic Thickness 33.6 ± 1.6 Å
Tilt Angle 0 ± 0°
ΔGtransfer -38.1 kcal/mol
ΔGfold -21.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 575-603 (574-604)
Pathways

Toll-like receptor signaling pathway (KEGG)

Tuberculosis (KEGG)

PDB 1fyv (625-785), 2z7x (B=25-475)
OPM none
Complexes

TLR2:TLR1_HUMAN

Interactions

TLR10, Complex: TLR1:TLR10, PubMed

TLR2, Complex: TLR1:TLR2, PDBID: 2z7x, PubMed

TLR4, Complex: TLR1:TLR4, PubMed

TLR5, Complex: TLR5:TLR1, PubMed

TLR9, Complex: TLR9:TLR1, PubMed

Domains

AA: 69-126, PDBID: 2Z7X, Subunit B, Seq Identity:100%, Leucine rich repeat

AA: 445-502, PDBID: 2Z7X, Subunit B, Seq Identity:100%, Leucine rich repeat

AA: 553-578, PDBID: 4V2C, Subunit C, Seq Identity:36%, Leucine rich repeat C-terminal domain

AA: 636-786, PDBID: 1FYV, Subunit A, Seq Identity:100%, TIR domain

UniProt annotation for TLR1_HUMAN » Toll-like receptor 1
FUNCTION: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).

SUBUNIT: Binds MYD88 (via TIR domain). Interacts with CNPY3 (By similarity). Interacts (via extracellular domain) with TLR2. Ligand binding induces the formation of a heterodimer with TLR2.

TISSUE SPECIFICITY: Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine.

UniProt features for TLR1_HUMAN » Toll-like receptor 1
SIGNAL 1 24
CHAIN 25 786 Toll-like receptor 1.
REPEAT 54 77 LRR 1.
REPEAT 78 101 LRR 2.
REPEAT 102 125 LRR 3.
REPEAT 126 150 LRR 4.
REPEAT 151 175 LRR 5.
REPEAT 176 199 LRR 6.
REPEAT 200 223 LRR 7.
REPEAT 224 250 LRR 8.
REPEAT 251 278 LRR 9.
REPEAT 279 308 LRR 10.
REPEAT 309 337 LRR 11.
REPEAT 338 361 LRR 12.
REPEAT 362 388 LRR 13.
REPEAT 389 414 LRR 14.
REPEAT 415 437 LRR 15.
REPEAT 438 457 LRR 16.
REPEAT 458 478 LRR 17.
REPEAT 479 500 LRR 18.
REPEAT 501 524 LRR 19.
DOMAIN 525 579 LRRCT.
DOMAIN 635 779 TIR.
REGION 313 316 Interaction with bacterial lipopeptide.
DISULFID 110 132
DISULFID 223 230
DISULFID 343 368
DISULFID 419 442
Amino Acid Sequence for TLR1_HUMAN » Toll-like receptor 1
MTSIFHFAII FMLILQIRIQ LSEESEFLVD RSKNGLIHVP KDLSQKTTIL NISQNYISEL WTSDILSLSK LRILIISHNR IQYLDISVFK FNQELEYLDL SHNKLVKISC HPTVNLKHLD LSFNAFDALP ICKEFGNMSQ LKFLGLSTTH LEKSSVLPIA HLNISKVLLV LGETYGEKED PEGLQDFNTE SLHIVFPTNK EFHFILDVSV KTVANLELSN IKCVLEDNKC SYFLSILAKL QTNPKLSNLT LNNIETTWNS FIRILQLVWH TTVWYFSISN VKLQGQLDFR DFDYSGTSLK ALSIHQVVSD VFGFPQSYIY EIFSNMNIKN FTVSGTRMVH MLCPSKISPF LHLDFSNNLL TDTVFENCGH LTELETLILQ MNQLKELSKI AEMTTQMKSL QQLDISQNSV SYDEKKGDCS WTKSLLSLNM SSNILTDTIF RCLPPRIKVL DLHSNKIKSI PKQVVKLEAL QELNVAFNSL TDLPGCGSFS SLSVLIIDHN SVSHPSADFF QSCQKMRSIK AGDNPFQCTC ELGEFVKNID QVSSEVLEGW PDSYKCDYPE SYRGTLLKDF HMSELSCNIT LLIVTIVATM LVLAVTVTSL CSYLDLPWYL RMVCQWTQTR RRARNIPLEE LQRNLQFHAF ISYSGHDSFW VKNELLPNLE KEGMQICLHE RNFVPGKSIV ENIITCIEKS YKSIFVLSPN FVQSEWCHYE LYFAHHNLFH EGSNSLILIL LEPIPQYSIP SSYHKLKSLM ARRTYLEWPK EKSKRGLFWA NLRAAINIKL TEQAKK