TLR10_HUMAN » Toll-like receptor 10

TLR10_HUMAN » Toll-like receptor 10
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TLR10_HUMAN » Toll-like receptor 10 »
Hydrophobic Thickness 39.2 ± 1.4 Å
Tilt Angle 2 ± 1°
ΔGtransfer -42.7 kcal/mol
ΔGfold -25.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 571-603 (571-603)
Pathways

Immune System (Reactome)

PDB 2j67 (A/B=622-776)
OPM none
Complexes

TLR10:TLR10_HUMAN

Interactions

FUT7, Complex: TLR10:FUT7, PubMed

TLR10, Complex: Homodimer of toll-like receptor 10, PDBID: 2J67

TLR1, Complex: TLR1:TLR10, PubMed

TLR2, Complex: TLR10:TLR2, PubMed

TLR2, Complex: TLR2:MYD88:TLR10, PubMed

Domains

AA: 50-71, PDBID: 3B2D, Subunit A, Seq Identity:38%, Leucine Rich Repeat

AA: 72-129, PDBID: 2Z7X, Subunit B, Seq Identity:57%, Leucine rich repeat

AA: 633-802, PDBID: 2J67, Subunit B, Seq Identity:100%, TIR domain

UniProt annotation for TLR10_HUMAN » Toll-like receptor 10
FUNCTION: Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).

SUBUNIT: Binds MYD88 via their respective TIR domains (By similarity). Homodimer (Potential).

TISSUE SPECIFICITY: Highly expressed in spleen, lymph node, thymus, tonsil and at lower levels in lung. Highly expressed in promyelocytic HL-60 cells and in B-cell lines.

UniProt features for TLR10_HUMAN » Toll-like receptor 10
SIGNAL 1 19 Potential.
CHAIN 20 811 Toll-like receptor 10.
REPEAT 24 46 LRR 1.
REPEAT 49 70 LRR 2.
REPEAT 73 94 LRR 3.
REPEAT 97 118 LRR 4.
REPEAT 119 139 LRR 5.
REPEAT 143 166 LRR 6.
REPEAT 296 321 LRR 7.
REPEAT 325 348 LRR 8.
REPEAT 349 368 LRR 9.
REPEAT 373 394 LRR 10.
REPEAT 398 419 LRR 11.
REPEAT 422 442 LRR 12.
REPEAT 444 465 LRR 13.
REPEAT 467 488 LRR 14.
REPEAT 489 509 LRR 15.
DOMAIN 522 576 LRRCT.
DOMAIN 632 778 TIR.
Amino Acid Sequence for TLR10_HUMAN » Toll-like receptor 10
MRLIRNIYIF CSIVMTAEGD APELPEEREL MTNCSNMSLR KVPADLTPAT TTLDLSYNLL FQLQSSDFHS VSKLRVLILC HNRIQQLDLK TFEFNKELRY LDLSNNRLKS VTWYLLAGLR YLDLSFNDFD TMPICEEAGN MSHLEILGLS GAKIQKSDFQ KIAHLHLNTV FLGFRTLPHY EEGSLPILNT TKLHIVLPMD TNFWVLLRDG IKTSKILEMT NIDGKSQFVS YEMQRNLSLE NAKTSVLLLN KVDLLWDDLF LILQFVWHTS VEHFQIRNVT FGGKAYLDHN SFDYSNTVMR TIKLEHVHFR VFYIQQDKIY LLLTKMDIEN LTISNAQMPH MLFPNYPTKF QYLNFANNIL TDELFKRTIQ LPHLKTLILN GNKLETLSLV SCFANNTPLE HLDLSQNLLQ HKNDENCSWP ETVVNMNLSY NKLSDSVFRC LPKSIQILDL NNNQIQTVPK ETIHLMALRE LNIAFNFLTD LPGCSHFSRL SVLNIEMNFI LSPSLDFVQS CQEVKTLNAG RNPFRCTCEL KNFIQLETYS EVMMVGWSDS YTCEYPLNLR GTRLKDVHLH ELSCNTALLI VTIVVIMLVL GLAVAFCCLH FDLPWYLRML GQCTQTWHRV RKTTQEQLKR NVRFHAFISY SEHDSLWVKN ELIPNLEKED GSILICLYES YFDPGKSISE NIVSFIEKSY KSIFVLSPNF VQNEWCHYEF YFAHHNLFHE NSDHIILILL EPIPFYCIPT RYHKLKALLE KKAYLEWPKD RRKCGLFWAN LRAAINVNVL ATREMYELQT FTELNEESRG STISLMRTDC L