TIP_HUMAN » T-cell immunomodulatory protein

TIP_HUMAN » T-cell immunomodulatory protein
Magnify TIP_HUMAN » T-cell immunomodulatory proteinEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Vesicle membrane
Topologyvesicle lumenal side
cytoplasmic side
TIP_HUMAN » T-cell immunomodulatory protein » Protein TIP; Integrin-alpha FG-GAP repeat-containing protein 1;
Hydrophobic Thickness 38.8 ± 5.6 Å
Tilt Angle 7 ± 5°
ΔGtransfer -26.9 kcal/mol
ΔGfold -25.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 565-590 (563-595)
Pathways none
PDB none
OPM none
Complexes none
Interactions

TNR14, Complex: TNR14:TIP, PubMed

Domains

AA: 55-118, Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

UniProt annotation for TIP_HUMAN » T-cell immunomodulatory protein
FUNCTION: Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity).

TISSUE SPECIFICITY: Ubiquitously expressed.

UniProt features for TIP_HUMAN » T-cell immunomodulatory protein
SIGNAL 1 33 Potential.
CHAIN 34 612 T-cell immunomodulatory protein.
REPEAT 258 293 FG-GAP; atypical.
Amino Acid Sequence for TIP_HUMAN » T-cell immunomodulatory protein
MAAAGRLPSS WALFSPLLAG LALLGVGPVP ARALHNVTAE LFGAEAWGTL AAFGDLNSDK QTDLFVLRER NDLIVFLADQ NAPYFKPKVK VSFKNHSALI TSVVPGDYDG DSQMDVLLTY LPKNYAKSEL GAVIFWGQNQ TLDPNNMTIL NRTFQDEPLI MDFNGDLIPD IFGITNESNQ PQILLGGNLS WHPALTTTSK MRIPHSHAFI DLTEDFTADL FLTTLNATTS TFQFEIWENL DGNFSVSTIL EKPQNMMVVG QSAFADFDGD GHMDHLLPGC EDKNCQKSTI YLVRSGMKQW VPVLQDFSNK GTLWGFVPFV DEQQPTEIPI PITLHIGDYN MDGYPDALVI LKNTSGSNQQ AFLLENVPCN NASCEEARRM FKVYWELTDL NQIKDAMVAT FFDIYEDGIL DIVVLSKGYT KNDFAIHTLK NNFEADAYFV KVIVLSGLCS NDCPRKITPF GVNQPGPYIM YTTVDANGYL KNGSAGQLSQ SAHLALQLPY NVLGLGRSAN FLDHLYVGIP RPSGEKSIRK QEWTAIIPNS QLIVIPYPHN VPRSWSAKLY LTPSNIVLLT AIALIGVCVF ILAIIGILHW QEKKADDREK RQEAHRFHFD AM