TIMD4_HUMAN » T-cell immunoglobulin and mucin domain-containing protein 4

TIMD4_HUMAN » T-cell immunoglobulin and mucin domain-containing protein 4
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TIMD4_HUMAN » T-cell immunoglobulin and mucin domain-containing protein 4 » TIMD-4; T-cell membrane protein 4;TIM-4;
Hydrophobic Thickness 34.8 ± 5.6 Å
Tilt Angle 28 ± 4°
ΔGtransfer -26.3 kcal/mol
ΔGfold -21.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 311-338 (309-341)
Pathways none
PDB none
OPM 3bib (MOUSE)
Complexes none
Interactions

HAVR1, Complex: HAVR1:TIMD4, PubMed

Domains

AA: 23-130, PDBID: 5DZN, Subunit E, Seq Identity:100%, Immunoglobulin V-set domain

UniProt annotation for TIMD4_HUMAN » T-cell immunoglobulin and mucin domain-containing protein 4
FUNCTION: Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1 (By similarity).

DOMAIN: Recognizes phosphatidyl serine via its immunoglobulin domain.

UniProt features for TIMD4_HUMAN » T-cell immunoglobulin and mucin domain-containing protein 4
SIGNAL 1 24 Potential.
CHAIN 25 378 T-cell immunoglobulin and mucin domain- containing protein 4.
DOMAIN 25 126 Ig-like V-type.
DISULFID 40 112 By similarity.
DISULFID 53 64 By similarity.
DISULFID 59 111 By similarity.
Amino Acid Sequence for TIMD4_HUMAN » T-cell immunoglobulin and mucin domain-containing protein 4
MSKEPLILWL MIEFWWLYLT PVTSETVVTE VLGHRVTLPC LYSSWSHNSN SMCWGKDQCP YSGCKEALIR TDGMRVTSRK SAKYRLQGTI PRGDVSLTIL NPSESDSGVY CCRIEVPGWF NDVKINVRLN LQRASTTTHR TATTTTRRTT TTSPTTTRQM TTTPAALPTT VVTTPDLTTG TPLQMTTIAV FTTANTCLSL TPSTLPEEAT GLLTPEPSKE GPILTAESET VLPSDSWSSA ESTSADTVLL TSKESKVWDL PSTSHVSMWK TSDSVSSPQP GASDTAVPEQ NKTTKTGQMD GIPMSMKNEM PISQLLMIIA PSLGFVLFAL FVAFLLRGKL METYCSQKHT RLDYIGDSKN VLNDVQHGRE DEDGLFTL