TIM50_HUMAN » Mitochondrial import inner membrane translocase subunit TIM50

TIM50_HUMAN » Mitochondrial import inner membrane translocase subunit TIM50
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Topology in Mitochondrial inner membrane
Topologyintermembrane space
mitochondrial matrix side
TIM50_HUMAN » Mitochondrial import inner membrane translocase subunit TIM50 »
Hydrophobic Thickness 30.0 ± 2.4 Å
Tilt Angle 21 ± 0°
ΔGtransfer -13.2 kcal/mol
ΔGfold -7.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 65-86 (60-86)
Pathways none
PDB none
OPM none
Complexes none
Interactions

DAF, Complex: TIM50:DAF, PubMed

EGFR, Complex: TIM50:EGFR

ERBB2, Complex: TIM50:ERBB2, PubMed

ERLN2, Complex: TIM50:ERLN2

RYK, Complex: TIM50:RYK, PubMed

SLMAP, Complex: SLMAP:TIM50, PubMed

TIM21, Complex: TIM50:TIM21

TNR1A, Complex: TIM50:TNR1A, PubMed

TNR1B, Complex: TNR1B:TIM50, PubMed

TOM70, Complex: TOM70:TIM50, PubMed

TOM7, Complex: TOM7:TIM50, PubMed

TR10B, Complex: TR10B:TIM50, PubMed

VAMP2, Complex: VAMP2:TIM50, PubMed

Domains

AA: 148-295, PDBID: 4QQF, Subunit D, Seq Identity:46%, NLI interacting factor-like phosphatase

UniProt annotation for TIM50_HUMAN » Mitochondrial import inner membrane translocase subunit TIM50
FUNCTION: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. Isoform 2 may participate in the release of snRNPs and SMN from the Cajal body.

SUBUNIT: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50; within this complex, directly interacts with TIMM23. The complex interacts with the TIMM44 component of the PAM complex and with DNAJC15. Isoform 2 interacts with COIL and snRNPs.

TISSUE SPECIFICITY: Widely expressed. Expressed at higher level in brain, kidney and liver (at protein level).

DOMAIN: The FCP1 homology domain does not contain the canonical D- x-D-x-[TV] active site, suggesting that it probably does not display phosphatase activity in vivo.

UniProt features for TIM50_HUMAN » Mitochondrial import inner membrane translocase subunit TIM50
TRANSIT 1 44 Mitochondrion (Potential).
CHAIN 45 353 Mitochondrial import inner membrane translocase subunit TIM50.
DOMAIN 143 286 FCP1 homology.
Amino Acid Sequence for TIM50_HUMAN » Mitochondrial import inner membrane translocase subunit TIM50
MAASAAVFSR LRSGLRLGSR GLCTRLATPP RRAPDQAAEI GSRGSTKAQG PQQQPGSEGP SYAKKVALWL AGLLGAGGTV SVVYIFGNNP VDENGAKIPD EFDNDPILVQ QLRRTYKYFK DYRQMIIEPT SPCLLPDPLQ EPYYQPPYTL VLELTGVLLH PEWSLATGWR FKKRPGIETL FQQLAPLYEI VIFTSETGMT AFPLIDSVDP HGFISYRLFR DATRYMDGHH VKDISCLNRD PARVVVVDCK KEAFRLQPYN GVALRPWDGN SDDRVLLDLS AFLKTIALNG VEDVRTVLEH YALEDDPLAA FKQRQSRLEQ EEQQRLAELS KSNKQNLFLG SLTSRLWPRS KQP