TIM50_ARATH » Mitochondrial import inner membrane translocase subunit TIM50

TIM50_ARATH » Mitochondrial import inner membrane translocase subunit TIM50
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Topology in Mitochondrial inner membrane
Topologyintermembrane space
mitochondrial matrix side
TIM50_ARATH » Mitochondrial import inner membrane translocase subunit TIM50 » Protein EMBRYO DEFECTIVE 1860;
Hydrophobic Thickness 26.8 ± 1.1 Å
Tilt Angle 32 ± 1°
ΔGtransfer -12.6 kcal/mol
ΔGfold -9.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 83-104 (74-105)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 191-338, PDBID: 4QQF, Subunit D, Seq Identity:48%, NLI interacting factor-like phosphatase

UniProt annotation for TIM50_ARATH » Mitochondrial import inner membrane translocase subunit TIM50
FUNCTION: Essential component of the TIM17:23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.

SUBUNIT: Component of the TIM17:23 complex at least composed of TIM23, TIM17 and TIM50. Interacts with TIM23-2.

TISSUE SPECIFICITY: Expressed in young cotyledons, roots, flowers and leaves.

INDUCTION: Up-regulated after antimycin A or rotenone treatments.

UniProt features for TIM50_ARATH » Mitochondrial import inner membrane translocase subunit TIM50
TRANSIT 1 25 Mitochondrion (Potential).
CHAIN 26 376 Mitochondrial import inner membrane translocase subunit TIM50.
DOMAIN 186 329 FCP1 homology.
Amino Acid Sequence for TIM50_ARATH » Mitochondrial import inner membrane translocase subunit TIM50
MASIVLRSRL LPRLAKLRSR NLRCFSAEAS STNSTSRYSG VTSTQSMFSD FPPPNQPPPP PPPQVEAAAA AATGKERKGL KYLGYALLWA LTGATAATGY ASFAYTIDEV NEKTKAFRES ATKTPVIKSS GIDVIDKYQT KLYSAAMTGS ARAIDKYLEL REIVEEQVKG FTEPLSEKLL PDLHPAEQHV FTLVLDLNET LLYTDWKRER GWRTFKRPGV DAFLEHLGKF YEIVVYSDQM EMYVLPVCEK LDPNGYIRYK LARGATKYEN GKHYRDLSKL NRDPKKILFV SANAFESTLQ PENSVPIKPY KLEADDTALV DLIPFLEYVA RNSPADIRPV LASFERKDIA KEFIDRSIEY QKRKQGQLGQ GRFWRR