TIM21_HUMAN » Mitochondrial import inner membrane translocase subunit Tim21

TIM21_HUMAN » Mitochondrial import inner membrane translocase subunit Tim21
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Topology in Mitochondrial inner membrane
Topologyintermembrane space
mitochondrial matrix side
TIM21_HUMAN » Mitochondrial import inner membrane translocase subunit Tim21 » TIM21-like protein, mitochondrial;
Hydrophobic Thickness 28.0 ± 3.2 Å
Tilt Angle 26 ± 7°
ΔGtransfer -18.0 kcal/mol
ΔGfold -12.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 108-129 (108-129)
Pathways none
PDB none
OPM none
Complexes none
Interactions

COA1, Complex: COA1:TIM21

COA3, Complex: TIM21:COA3

COX41, Complex: TIM21:COX41

COX6C, Complex: TIM21:COX6C

ERBB2, Complex: TIM21:ERBB2, PubMed

NDUB8, Complex: TIM21:NDUB8

TIM50, Complex: TIM50:TIM21

Domains

AA: 100-244, PDBID: 2CIU, Subunit A, Seq Identity:21%, TIM21

UniProt annotation for TIM21_HUMAN » Mitochondrial import inner membrane translocase subunit Tim21
FUNCTION: Participates in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of some MITRAC complex, a cytochrome c oxidase (COX) assembly intermediate complex. TIM21 probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes.

SUBUNIT: Component of the TIM23 complex. Component of some MITRAC complex.

UniProt features for TIM21_HUMAN » Mitochondrial import inner membrane translocase subunit Tim21
TRANSIT 1 18 Mitochondrion (Potential).
CHAIN 19 248 Mitochondrial import inner membrane translocase subunit Tim21.
Amino Acid Sequence for TIM21_HUMAN » Mitochondrial import inner membrane translocase subunit Tim21
MICTFLRAVQ YTEKLHRSSA KRLLLPYIVL NKACLKTEPS LRCGLQYQKK TLRPRCILGV TQKTIWTQGP SPRKAKEDGS KQVSVHRSQR GGTAVPTSQK VKEAGRDFTY LIVVLFGISI TGGLFYTIFK ELFSSSSPSK IYGRALEKCR SHPEVIGVFG ESVKGYGEVT RRGRRQHVRF TEYVKDGLKH TCVKFYIEGS EPGKQGTVYA QVKENPGSGE YDFRYIFVEI ESYPRRTIII EDNRSQDD