TIGIT_HUMAN » T-cell immunoreceptor with Ig and ITIM domains

TIGIT_HUMAN » T-cell immunoreceptor with Ig and ITIM domains
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TIGIT_HUMAN » T-cell immunoreceptor with Ig and ITIM domains » V-set and immunoglobulin domain-containing protein 9;V-set and transmembrane domain-containing protein 3;
Hydrophobic Thickness 37.6 ± 1.4 Å
Tilt Angle 4 ± 1°
ΔGtransfer -54.3 kcal/mol
ΔGfold -21.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 138-166 (131-168)
Pathways

Cell adhesion molecules (KEGG)

PDB 3q0h (22-137), 3ucr (A/B/C/D=23-128), 3udw (A/B=20-128), 3rq3 (A/B=22-137)
OPM none
Complexes

TIGIT:PVR_HUMAN

TIGIT:TIGIT_HUMAN

Interactions

PVRL2, Complex: PVRL2:TIGIT

PVRL3, Complex: PVRL3:TIGIT

PVRL4, Complex: PVRL4:TIGIT

PVR, Complex: TIGIT:PVR, PDBID: 3UDW

TIGIT, Complex: Homodimer of T-cell immunoreceptor with Ig and ITIM domains, PDBID: 3UCR

Domains

AA: 28-127, PDBID: 3Q0H, Subunit A, Seq Identity:100%, Immunoglobulin V-set domain

UniProt annotation for TIGIT_HUMAN » T-cell immunoreceptor with Ig and ITIM domains
FUNCTION: Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

SUBUNIT: Homodimer in cis; binds with high affinity to PVR, forming a heterotetrameric assembly of two TIGIT and two PVR molecules. Binds with lower affinity to PVRL2 and PVRL3.

TISSUE SPECIFICITY: Expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level).

DOMAIN: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases.

UniProt features for TIGIT_HUMAN » T-cell immunoreceptor with Ig and ITIM domains
SIGNAL 1 21 Potential.
CHAIN 22 244 T-cell immunoreceptor with Ig and ITIM domains.
DOMAIN 22 124 Ig-like V-type.
MOTIF 229 234 ITIM motif.
DISULFID 45 108 By similarity.
Amino Acid Sequence for TIGIT_HUMAN » T-cell immunoreceptor with Ig and ITIM domains
MRWCLLLIWA QGLRQAPLAS GMMTGTIETT GNISAEKGGS IILQCHLSST TAQVTQVNWE QQDQLLAICN ADLGWHISPS FKDRVAPGPG LGLTLQSLTV NDTGEYFCIY HTYPDGTYTG RIFLEVLESS VAEHGARFQI PLLGAMAATL VVICTAVIVV VALTRKKKAL RIHSVEGDLR RKSAGQEEWS PSAPSPPGSC VQAEAAPAGL CGEQRGEDCA ELHDYFNVLS YRSLGNCSFF TETG