TIE1_HUMAN » Tyrosine-protein kinase receptor Tie-1

TIE1_HUMAN » Tyrosine-protein kinase receptor Tie-1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TIE1_HUMAN » Tyrosine-protein kinase receptor Tie-1 »
Hydrophobic Thickness 41.2 ± 2.0 Å
Tilt Angle 1 ± 0°
ΔGtransfer -39.6 kcal/mol
ΔGfold -18.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 761-786 (759-789)
Pathways none
PDB none
OPM none
Complexes none
Interactions

PTPRC, Complex: PTPRC:TIE1, PubMed

PTPRG, Complex: PTPRG:TIE1, PubMed

PTPRJ, Complex: PTPRJ:TIE1, PubMed

TIE2, Complex: TIE1:TIE2, PubMed

Domains

AA: 129-210, PDBID: 1N26, Subunit A, Seq Identity:27%, Immunoglobulin domain

AA: 356-441, PDBID: 2CKN, Subunit A, Seq Identity:27%, Immunoglobulin domain

AA: 448-533, PDBID: 1X5A, Subunit A, Seq Identity:32%, Fibronectin type III domain

AA: 548-632, PDBID: 2DB8, Subunit A, Seq Identity:31%, Fibronectin type III domain

AA: 645-729, PDBID: 4WTX, Subunit A, Seq Identity:30%, Fibronectin type III domain

AA: 839-1107, PDBID: 1FVR, Subunit A, Seq Identity:74%, Protein tyrosine kinase

UniProt annotation for TIE1_HUMAN » Tyrosine-protein kinase receptor Tie-1
FUNCTION: Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.

CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

SUBUNIT: Heterodimer with TEK/TIE2.

TISSUE SPECIFICITY: Specifically expressed in developing vascular endothelial cells.

UniProt features for TIE1_HUMAN » Tyrosine-protein kinase receptor Tie-1
SIGNAL 1 21
CHAIN 22 1138 Tyrosine-protein kinase receptor Tie-1.
DOMAIN 43 105 Ig-like C2-type 1.
DOMAIN 214 256 EGF-like 1.
DOMAIN 258 303 EGF-like 2.
DOMAIN 305 345 EGF-like 3.
DOMAIN 372 426 Ig-like C2-type 2.
DOMAIN 446 537 Fibronectin type-III 1.
DOMAIN 545 637 Fibronectin type-III 2.
DOMAIN 644 736 Fibronectin type-III 3.
DOMAIN 839 1118 Protein kinase.
ACT_SITE 979 979 Proton acceptor (By similarity).
DISULFID 228 237 By similarity.
DISULFID 231 244 By similarity.
DISULFID 246 255 By similarity.
DISULFID 315 327 By similarity.
DISULFID 321 333 By similarity.
DISULFID 335 344 By similarity.
Amino Acid Sequence for TIE1_HUMAN » Tyrosine-protein kinase receptor Tie-1
MVWRVPPFLL PILFLASHVG AAVDLTLLAN LRLTDPQRFF LTCVSGEAGA GRGSDAWGPP LLLEKDDRIV RTPPGPPLRL ARNGSHQVTL RGFSKPSDLV GVFSCVGGAG ARRTRVIYVH NSPGAHLLPD KVTHTVNKGD TAVLSARVHK EKQTDVIWKS NGSYFYTLDW HEAQDGRFLL QLPNVQPPSS GIYSATYLEA SPLGSAFFRL IVRGCGAGRW GPGCTKECPG CLHGGVCHDH DGECVCPPGF TGTRCEQACR EGRFGQSCQE QCPGISGCRG LTFCLPDPYG CSCGSGWRGS QCQEACAPGH FGADCRLQCQ CQNGGTCDRF SGCVCPSGWH GVHCEKSDRI PQILNMASEL EFNLETMPRI NCAAAGNPFP VRGSIELRKP DGTVLLSTKA IVEPEKTTAE FEVPRLVLAD SGFWECRVST SGGQDSRRFK VNVKVPPVPL AAPRLLTKQS RQLVVSPLVS FSGDGPISTV RLHYRPQDST MDWSTIVVDP SENVTLMNLR PKTGYSVRVQ LSRPGEGGEG AWGPPTLMTT DCPEPLLQPW LEGWHVEGTD RLRVSWSLPL VPGPLVGDGF LLRLWDGTRG QERRENVSSP QARTALLTGL TPGTHYQLDV QLYHCTLLGP ASPPAHVLLP PSGPPAPRHL HAQALSDSEI QLTWKHPEAL PGPISKYVVE VQVAGGAGDP LWIDVDRPEE TSTIIRGLNA STRYLFRMRA SIQGLGDWSN TVEESTLGNG LQAEGPVQES RAAEEGLDQQ LILAVVGSVS ATCLTILAAL LTLVCIRRSC LHRRRTFTYQ SGSGEETILQ FSSGTLTLTR RPKLQPEPLS YPVLEWEDIT FEDLIGEGNF GQVIRAMIKK DGLKMNAAIK MLKEYASEND HRDFAGELEV LCKLGHHPNI INLLGACKNR GYLYIAIEYA PYGNLLDFLR KSRVLETDPA FAREHGTAST LSSRQLLRFA SDAANGMQYL SEKQFIHRDL AARNVLVGEN LASKIADFGL SRGEEVYVKK TMGRLPVRWM AIESLNYSVY TTKSDVWSFG VLLWEIVSLG GTPYCGMTCA ELYEKLPQGY RMEQPRNCDD EVYELMRQCW RDRPYERPPF AQIALQLGRM LEARKAYVNM SLFENFTYAG IDATAEEA