TGON2_HUMAN » Trans-Golgi network integral membrane protein 2

TGON2_HUMAN » Trans-Golgi network integral membrane protein 2
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Topology in Golgi apparatus membrane
TopologyGolgi lumenal side
cytoplasmic side
TGON2_HUMAN » Trans-Golgi network integral membrane protein 2 » TGN38 homolog;TGN46;TGN48;Trans-Golgi network protein TGN51;
Hydrophobic Thickness 27.6 ± 1.6 Å
Tilt Angle 26 ± 3°
ΔGtransfer -21.9 kcal/mol
ΔGfold -18.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 385-403 (379-408)
Pathways

Membrane Trafficking (Reactome)

PDB none
OPM none
Complexes none
Interactions

FURIN, Complex: TGON2:FURIN, PubMed

ITB1, Complex: TGON2:ITB1, PubMed

MMP14, Complex: TGON2:MMP14, PubMed

MPRI, Complex: MPRI:TGON2, PubMed

NICA, Complex: TGON2:NICA, PubMed

SYT2, Complex: TGON2:SYT2, PubMed

Domains none
UniProt annotation for TGON2_HUMAN » Trans-Golgi network integral membrane protein 2
FUNCTION: May be involved in regulating membrane traffic to and from trans-Golgi network.

TISSUE SPECIFICITY: Isoform TGN46 is widely expressed. Isoform TGN51 is more abundant in fetal lung and kidney. Isoform TGN48 is barely expressed in embryonic kidney and promyelocytic cells.

UniProt features for TGON2_HUMAN » Trans-Golgi network integral membrane protein 2
SIGNAL 1 21 Potential.
CHAIN 22 480 Trans-Golgi network integral membrane protein 2.
REPEAT 54 67 1.
REPEAT 68 81 2.
REPEAT 82 95 3.
REPEAT 96 109 4.
REPEAT 110 123 5.
REPEAT 124 137 6.
REPEAT 138 151 7.
REPEAT 152 165 8.
REPEAT 166 179 9.
REPEAT 180 193 10.
REPEAT 194 207 11.
REPEAT 208 221 12.
REPEAT 222 234 13.
REPEAT 235 249 14.
REGION 54 249 14 X 14 AA tandem repeats.
MOTIF 430 433 Endocytosis signal; in isoform TGN46 and isoform TGN48.
MOTIF 437 440 Endocytosis signal; in isoform TGN51.
MOTIF 461 464 Endocytosis signal; in isoform TGN51.
Amino Acid Sequence for TGON2_HUMAN » Trans-Golgi network integral membrane protein 2
MRFVVALVLL NVAAAGAVPL LATESVKQEE AGVRPSAGNV STHPSLSQRP GGSTKSHPEP QTPKDSPSKS SAEAQTPEDT PNKSGAEAKT QKDSSNKSGA EAKTQKGSTS KSGSEAQTTK DSTSKSHPEL QTPKDSTGKS GAEAQTPEDS PNRSGAEAKT QKDSPSKSGS EAQTTKDVPN KSGADGQTPK DGSSKSGAED QTPKDVPNKS GAEKQTPKDG SNKSGAEEQG PIDGPSKSGA EEQTSKDSPN KVVPEQPSRK DHSKPISNPS DNKELPKADT NQLADKGKLS PHAFKTESGE ETDLISPPQE EVKSSEPTED VEPKEAEDDD TGPEEGSPPK EEKEKMSGSA SSENREGTLS DSTGSEKDDL YPNGSGNGSA ESSHFFAYLV TAAILVAVLY IAHHNKRKII AFVLEGKRSK VTRRPKASDY QRLDQKYVLI LNVFPAPPKR SFLPQVLTEW YIPLEKDERH QWIVLLSFQL