TGFA_HUMAN » Protransforming growth factor alpha

TGFA_HUMAN » Protransforming growth factor alpha
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TGFA_HUMAN » Protransforming growth factor alpha »
Hydrophobic Thickness 36.0 ± 3.8 Å
Tilt Angle 29 ± 25°
ΔGtransfer -28.6 kcal/mol
ΔGfold -22.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 96-124 (93-129)
Pathways

ErbB signaling pathway (KEGG)

Glioma (KEGG)

Non-small cell lung cancer (KEGG)

Pancreatic cancer (KEGG)

Pathways in cancer (KEGG)

Prostate cancer (KEGG)

Renal cell carcinoma (KEGG)

PDB 1yuf (40-89), 1yug (40-89), 2tgf (40-89), 3tgf (40-89), 4tgf (40-89), 1gk5 (83-89), 1mox (C/D=40-89), 3e50 (C/D=40-89)
OPM none
Complexes

TGFA:EGFR_HUMAN

Interactions

ADA10, Complex: TGFA:ADA10, PubMed

ADA17, Complex: TGFA:ADA17, PubMed

EGFR, Complex: EGFR:TGFA, PDBID: 1mox

EGF, Complex: EGF:TGFA, PDBID: 1gk5

ERBB2, Complex: ERBB2:TGFA, PubMed

ERBB4, Complex: TGFA:ERBB4, PubMed

TMEDA, Complex: TGFA:TMEDA:GORS1, PubMed

Domains none
UniProt annotation for TGFA_HUMAN » Protransforming growth factor alpha
FUNCTION: TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.

SUBUNIT: Interacts with the PDZ domains of MAGI3, SDCBP and SNTA1. The interaction with SDCBP, is required for the targeting to the cell surface. In the endoplasmic reticulum, in its immature form (i.e. with a prosegment and lacking full N-glycosylation), interacts with CNIH. In the Golgi apparatus, may form a complex with CNIH and GORASP2. Interacts (via cytoplasmic C-terminal domain) with NKD2.

TISSUE SPECIFICITY: Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines.

UniProt features for TGFA_HUMAN » Protransforming growth factor alpha
SIGNAL 1 23 Potential.
CHAIN 24 160 Protransforming growth factor alpha.
PROPEP 24 39 Removed in mature form.
CHAIN 40 89 Transforming growth factor alpha.
PROPEP 90 160 Removed in mature form.
DOMAIN 43 83 EGF-like.
DISULFID 47 60
DISULFID 55 71
DISULFID 73 82
Amino Acid Sequence for TGFA_HUMAN » Protransforming growth factor alpha
MVPSAGQLAL FALGIVLAAC QALENSTSPL SADPPVAAAV VSHFNDCPDS HTQFCFHGTC RFLVQEDKPA CVCHSGYVGA RCEHADLLAV VAASQKKQAI TALVVVSIVA LAVLIITCVL IHCCQVRKHC EWCRALICRH EKPSALLKGR TACCHSETVV