TGBR3_HUMAN » Transforming growth factor beta receptor type 3

TGBR3_HUMAN » Transforming growth factor beta receptor type 3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TGBR3_HUMAN » Transforming growth factor beta receptor type 3 » TGF-beta receptor type 3; TGFR-3; Betaglycan;Transforming growth factor beta receptor III;TGF-beta receptor type III;
Hydrophobic Thickness 33.2 ± 1.6 Å
Tilt Angle 0 ± 0°
ΔGtransfer -48.2 kcal/mol
ΔGfold -21.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 783-809 (783-810)
Pathways none
PDB none
OPM 3qw9 (RAT)
Complexes none
Interactions

ACVL1, Complex: ACVL1:TGBR3, PubMed

AVR2A, Complex: AVR2A:TGBR3:INHA, PubMed

EGLN, Complex: EGLN:TGBR3, PubMed

NRP1, Complex: TGBR3:NRP1

SDC2, Complex: SDC2:TGBR3, PubMed

TGFR1, Complex: TGFR1:TGBR3

TGFR2, Complex: TGBR3:TGFR2, PubMed

Domains

AA: 456-724, PDBID: 3QW9, Subunit A, Seq Identity:78%, Zona pellucida-like domain

UniProt annotation for TGBR3_HUMAN » Transforming growth factor beta receptor type 3
FUNCTION: Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.

SUBUNIT: Interacts with TCTEX1D4.

UniProt features for TGBR3_HUMAN » Transforming growth factor beta receptor type 3
SIGNAL 1 20 Potential.
CHAIN 21 851 Transforming growth factor beta receptor type 3.
DOMAIN 455 730 ZP.
DISULFID 639 705 By similarity.
DISULFID 660 730 By similarity.
Amino Acid Sequence for TGBR3_HUMAN » Transforming growth factor beta receptor type 3
MTSHYVIAIF ALMSSCLATA GPEPGALCEL SPVSASHPVQ ALMESFTVLS GCASRGTTGL PQEVHVLNLR TAGQGPGQLQ REVTLHLNPI SSVHIHHKSV VFLLNSPHPL VWHLKTERLA TGVSRLFLVS EGSVVQFSSA NFSLTAETEE RNFPHGNEHL LNWARKEYGA VTSFTELKIA RNIYIKVGED QVFPPKCNIG KNFLSLNYLA EYLQPKAAEG CVMSSQPQNE EVHIIELITP NSNPYSAFQV DITIDIRPSQ EDLEVVKNLI LILKCKKSVN WVIKSFDVKG SLKIIAPNSI GFGKESERSM TMTKSIRDDI PSTQGNLVKW ALDNGYSPIT SYTMAPVANR FHLRLENNEE MGDEEVHTIP PELRILLDPG ALPALQNPPI RGGEGQNGGL PFPFPDISRR VWNEEGEDGL PRPKDPVIPS IQLFPGLREP EEVQGSVDIA LSVKCDNEKM IVAVEKDSFQ ASGYSGMDVT LLDPTCKAKM NGTHFVLESP LNGCGTRPRW SALDGVVYYN SIVIQVPALG DSSGWPDGYE DLESGDNGFP GDMDEGDASL FTRPEIVVFN CSLQQVRNPS SFQEQPHGNI TFNMELYNTD LFLVPSQGVF SVPENGHVYV EVSVTKAEQE LGFAIQTCFI SPYSNPDRMS HYTIIENICP KDESVKFYSP KRVHFPIPQA DMDKKRFSFV FKPVFNTSLL FLQCELTLCT KMEKHPQKLP KCVPPDEACT SLDASIIWAM MQNKKTFTKP LAVIHHEAES KEKGPSMKEP NPISPPIFHG LDTLTVMGIA FAAFVIGALL TGALWYIYSH TGETAGRQQV PTSPPASENS SAAHSIGSTQ STPCSSSSTA