TEN4_HUMAN » Teneurin-4

TEN4_HUMAN » Teneurin-4
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TEN4_HUMAN » Teneurin-4 » Ten-4; Protein Odd Oz/ten-m homolog 4;Tenascin-M4;Ten-m4; Teneurin transmembrane protein 4;
Hydrophobic Thickness 34.0 ± 1.8 Å
Tilt Angle 2 ± 2°
ΔGtransfer -45.1 kcal/mol
ΔGfold -22.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 339-368 (336-368)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 11-170, Teneurin Intracellular Region

AA: 163-340, Teneurin Intracellular Region

AA: 626-657, PDBID: 4Z80, Subunit A, Seq Identity:43%, EGF-like domain

AA: 729-755, PDBID: 4Z80, Subunit A, Seq Identity:45%, EGF-like domain

AA: 2685-2762, GHH signature containing HNH/Endo VII superfamily nuclease toxin

UniProt annotation for TEN4_HUMAN » Teneurin-4
FUNCTION: Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small- diameter axons in the central nervous system (CNS). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer (By similarity).

SUBUNIT: Homodimer; disulfide-linked (Probable). May also form heterodimer with either TENM1 or TENM2 or TENM3 (By similarity).

DOMAIN: EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds.

DOMAIN: Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins.

UniProt features for TEN4_HUMAN » Teneurin-4
CHAIN 1 2769 Teneurin-4.
DOMAIN 1 341 Teneurin N-terminal.
DOMAIN 562 593 EGF-like 1.
DOMAIN 594 624 EGF-like 2.
DOMAIN 626 658 EGF-like 3.
DOMAIN 659 690 EGF-like 4.
DOMAIN 692 725 EGF-like 5.
DOMAIN 726 757 EGF-like 6.
DOMAIN 758 787 EGF-like 7.
DOMAIN 788 831 EGF-like 8.
REPEAT 1216 1259 NHL 1.
REPEAT 1264 1308 NHL 2.
REPEAT 1334 1378 NHL 3.
REPEAT 1393 1444 NHL 4.
REPEAT 1523 1566 NHL 5.
REPEAT 1576 1595 YD 1.
REPEAT 1612 1632 YD 2.
REPEAT 1675 1694 YD 3.
REPEAT 1695 1717 YD 4.
REPEAT 1887 1906 YD 5.
REPEAT 1928 1946 YD 6.
REPEAT 1947 1967 YD 7.
REPEAT 1974 1991 YD 8.
REPEAT 1992 2013 YD 9.
REPEAT 2014 2031 YD 10.
REPEAT 2034 2054 YD 11.
REPEAT 2057 2077 YD 12.
REPEAT 2085 2104 YD 13.
REPEAT 2110 2127 YD 14.
REPEAT 2128 2154 YD 15.
REPEAT 2156 2169 YD 16.
REPEAT 2170 2193 YD 17.
REPEAT 2196 2216 YD 18.
REPEAT 2217 2237 YD 19.
REPEAT 2239 2259 YD 20.
REPEAT 2271 2291 YD 21.
REPEAT 2293 2313 YD 22.
REPEAT 2339 2380 YD 23.
DISULFID 566 576 By similarity.
DISULFID 570 581 By similarity.
DISULFID 583 592 By similarity.
DISULFID 601 612 By similarity.
DISULFID 614 623 By similarity.
DISULFID 630 641 By similarity.
DISULFID 635 646 By similarity.
DISULFID 648 657 By similarity.
DISULFID 662 673 By similarity.
DISULFID 667 678 By similarity.
DISULFID 680 689 By similarity.
DISULFID 700 713 By similarity.
DISULFID 715 724 By similarity.
DISULFID 729 739 By similarity.
DISULFID 733 744 By similarity.
DISULFID 746 755 By similarity.
DISULFID 760 770 By similarity.
DISULFID 764 775 By similarity.
DISULFID 777 786 By similarity.
DISULFID 800 810 By similarity.
DISULFID 804 819 By similarity.
DISULFID 821 830 By similarity.
Amino Acid Sequence for TEN4_HUMAN » Teneurin-4
MDVKERKPYR SLTRRRDAER RYTSSSADSE EGKAPQKSYS SSETLKAYDQ DARLAYGSRV KDIVPQEAEE FCRTGANFTL RELGLEEVTP PHGTLYRTDI GLPHCGYSMG AGSDADMEAD TVLSPEHPVR LWGRSTRSGR SSCLSSRANS NLTLTDTEHE NTETDHPGGL QNHARLRTPP PPLSHAHTPN QHHAASINSL NRGNFTPRSN PSPAPTDHSL SGEPPAGGAQ EPAHAQENWL LNSNIPLETR NLGKQPFLGT LQDNLIEMDI LGASRHDGAY SDGHFLFKPG GTSPLFCTTS PGYPLTSSTV YSPPPRPLPR STFARPAFNL KKPSKYCNWK CAALSAIVIS ATLVILLAYF VAMHLFGLNW HLQPMEGQMY EITEDTASSW PVPTDVSLYP SGGTGLETPD RKGKGTTEGK PSSFFPEDSF IDSGEIDVGR RASQKIPPGT FWRSQVFIDH PVHLKFNVSL GKAALVGIYG RKGLPPSHTQ FDFVELLDGR RLLTQEARSL EGTPRQSRGT VPPSSHETGF IQYLDSGIWH LAFYNDGKES EVVSFLTTAI ESVDNCPSNC YGNGDCISGT CHCFLGFLGP DCGRASCPVL CSGNGQYMKG RCLCHSGWKG AECDVPTNQC IDVACSNHGT CITGTCICNP GYKGESCEEV DCMDPTCSGR GVCVRGECHC SVGWGGTNCE TPRATCLDQC SGHGTFLPDT GLCSCDPSWT GHDCSIEICA ADCGGHGVCV GGTCRCEDGW MGAACDQRAC HPRCAEHGTC RDGKCECSPG WNGEHCTIAH YLDRVVKEGC PGLCNGNGRC TLDLNGWHCV CQLGWRGAGC DTSMETACGD SKDNDGDGLV DCMDPDCCLQ PLCHINPLCL GSPNPLDIIQ ETQVPVSQQN LHSFYDRIKF LVGRDSTHII PGENPFDGGH ACVIRGQVMT SDGTPLVGVN ISFVNNPLFG YTISRQDGSF DLVTNGGISI ILRFERAPFI TQEHTLWLPW DRFFVMETII MRHEENEIPS CDLSNFARPN PVVSPSPLTS FASSCAEKGP IVPEIQALQE EISISGCKMR LSYLSSRTPG YKSVLRISLT HPTIPFNLMK VHLMVAVEGR LFRKWFAAAP DLSYYFIWDK TDVYNQKVFG LSEAFVSVGY EYESCPDLIL WEKRTTVLQG YEIDASKLGG WSLDKHHALN IQSGILHKGN GENQFVSQQP PVIGSIMGNG RRRSISCPSC NGLADGNKLL APVALTCGSD GSLYVGDFNY IRRIFPSGNV TNILELRNKD FRHSHSPAHK YYLATDPMSG AVFLSDSNSR RVFKIKSTVV VKDLVKNSEV VAGTGDQCLP FDDTRCGDGG KATEATLTNP RGITVDKFGL IYFVDGTMIR RIDQNGIIST LLGSNDLTSA RPLSCDSVMD ISQVHLEWPT DLAINPMDNS LYVLDNNVVL QISENHQVRI VAGRPMHCQV PGIDHFLLSK VAIHATLESA TALAVSHNGV LYIAETDEKK INRIRQVTTS GEISLVAGAP SGCDCKNDAN CDCFSGDDGY AKDAKLNTPS SLAVCADGEL YVADLGNIRI RFIRKNKPFL NTQNMYELSS PIDQELYLFD TTGKHLYTQS LPTGDYLYNF TYTGDGDITL ITDNNGNMVN VRRDSTGMPL WLVVPDGQVY WVTMGTNSAL KSVTTQGHEL AMMTYHGNSG LLATKSNENG WTTFYEYDSF GRLTNVTFPT GQVSSFRSDT DSSVHVQVET SSKDDVTITT NLSASGAFYT LLQDQVRNSY YIGADGSLRL LLANGMEVAL QTEPHLLAGT VNPTVGKRNV TLPIDNGLNL VEWRQRKEQA RGQVTVFGRR LRVHNRNLLS LDFDRVTRTE KIYDDHRKFT LRILYDQAGR PSLWSPSSRL NGVNVTYSPG GYIAGIQRGI MSERMEYDQA GRITSRIFAD GKTWSYTYLE KSMVLLLHSQ RQYIFEFDKN DRLSSVTMPN VARQTLETIR SVGYYRNIYQ PPEGNASVIQ DFTEDGHLLH TFYLGTGRRV IYKYGKLSKL AETLYDTTKV SFTYDETAGM LKTINLQNEG FTCTIRYRQI GPLIDRQIFR FTEEGMVNAR FDYNYDNSFR VTSMQAVINE TPLPIDLYRY DDVSGKTEQF GKFGVIYYDI NQIITTAVMT HTKHFDAYGR MKEVQYEIFR SLMYWMTVQY DNMGRVVKKE LKVGPYANTT RYSYEYDADG QLQTVSINDK PLWRYSYDLN GNLHLLSPGN SARLTPLRYD IRDRITRLGD VQYKMDEDGF LRQRGGDIFE YNSAGLLIKA YNRAGSWSVR YRYDGLGRRV SSKSSHSHHL QFFYADLTNP TKVTHLYNHS SSEITSLYYD LQGHLFAMEL SSGDEFYIAC DNIGTPLAVF SGTGLMIKQI LYTAYGEIYM DTNPNFQIII GYHGGLYDPL TKLVHMGRRD YDVLAGRWTS PDHELWKHLS SSNVMPFNLY MFKNNNPISN SQDIKCFMTD VNSWLLTFGF QLHNVIPGYP KPDMDAMEPS YELIHTQMKT QEWDNSKSIL GVQCEVQKQL KAFVTLERFD QLYGSTITSC QQAPKTKKFA SSGSVFGKGV KFALKDGRVT TDIISVANED GRRVAAILNH AHYLENLHFT IDGVDTHYFV KPGPSEGDLA ILGLSGGRRT LENGVNVTVS QINTVLNGRT RRYTDIQLQY GALCLNTRYG TTLDEEKARV LELARQRAVR QAWAREQQRL REGEEGLRAW TEGEKQQVLS TGRVQGYDGF FVISVEQYPE LSDSANNIHF MRQSEMGRR