TEN2_HUMAN » Teneurin-2

TEN2_HUMAN » Teneurin-2
Magnify TEN2_HUMAN » Teneurin-2Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TEN2_HUMAN » Teneurin-2 » Ten-2; Protein Odd Oz/ten-m homolog 2;Tenascin-M2;Ten-m2; Teneurin transmembrane protein 2;
Hydrophobic Thickness 33.6 ± 1.8 Å
Tilt Angle 0 ± 0°
ΔGtransfer -51.7 kcal/mol
ΔGfold -26.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 374-399 (370-402)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 10-374, Teneurin Intracellular Region

AA: 2690-2767, GHH signature containing HNH/Endo VII superfamily nuclease toxin

UniProt annotation for TEN2_HUMAN » Teneurin-2
FUNCTION: Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion (By similarity). May function as a cellular signal transducer.

FUNCTION: Isoform 2: Acts as a ligand of the LPHN1 receptor. Mediates axon guidance and heterophilic cell-cell adhesion.

FUNCTION: Ten-2 intracellular domain: Induces gene transcription inhibition.

SUBUNIT: Homodimer; disulfide-linked (Probable). Heterodimer with either TENM1 or TENM3. May also form heterodimer with TENM4 (By similarity). Isoform 2 (C-terminal globular domain) interacts with LPHN1 isoform 2.

TISSUE SPECIFICITY: Highly expressed in heart, followed by brain, liver, kidney and fetal brain and weakly expressed in lung and testis. No expression was detected in skeletal muscle, pancreas, spleen, ovary and fetal liver.

DOMAIN: EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds.

DOMAIN: Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins.

UniProt features for TEN2_HUMAN » Teneurin-2
CHAIN 1 2774 Teneurin-2.
CHAIN 1 ? Ten-2 intracellular domain (By similarity).
CHAIN 529 2774 Ten-2, soluble form (By similarity).
DOMAIN 1 375 Teneurin N-terminal.
DOMAIN 575 603 EGF-like 1.
DOMAIN 598 634 EGF-like 2.
DOMAIN 636 668 EGF-like 3.
DOMAIN 669 701 EGF-like 4.
DOMAIN 702 735 EGF-like 5.
DOMAIN 738 766 EGF-like 6.
DOMAIN 769 797 EGF-like 7.
DOMAIN 808 841 EGF-like 8.
REPEAT 1272 1316 NHL 1.
REPEAT 1342 1386 NHL 2.
REPEAT 1401 1452 NHL 3.
REPEAT 1474 1501 NHL 4.
REPEAT 1530 1573 NHL 5.
REPEAT 1583 1602 YD 1.
REPEAT 1619 1639 YD 2.
REPEAT 1682 1701 YD 3.
REPEAT 1702 1724 YD 4.
REPEAT 1895 1914 YD 5.
REPEAT 1936 1954 YD 6.
REPEAT 1955 1975 YD 7.
REPEAT 1982 1999 YD 8.
REPEAT 2000 2021 YD 9.
REPEAT 2022 2039 YD 10.
REPEAT 2042 2062 YD 11.
REPEAT 2065 2085 YD 12.
REPEAT 2093 2113 YD 13.
REPEAT 2119 2136 YD 14.
REPEAT 2137 2163 YD 15.
REPEAT 2165 2178 YD 16.
REPEAT 2179 2202 YD 17.
REPEAT 2205 2225 YD 18.
REPEAT 2226 2246 YD 19.
REPEAT 2248 2268 YD 20.
REPEAT 2280 2300 YD 21.
REPEAT 2302 2322 YD 22.
REPEAT 2348 2389 YD 23.
SITE 528 529 Cleavage (By similarity).
DISULFID 576 586 By similarity.
DISULFID 580 591 By similarity.
DISULFID 593 602 By similarity.
DISULFID 611 622 By similarity.
DISULFID 624 633 By similarity.
DISULFID 640 651 By similarity.
DISULFID 645 656 By similarity.
DISULFID 658 667 By similarity.
DISULFID 672 683 By similarity.
DISULFID 677 688 By similarity.
DISULFID 690 699 By similarity.
DISULFID 710 723 By similarity.
DISULFID 725 734 By similarity.
DISULFID 739 749 By similarity.
DISULFID 743 754 By similarity.
DISULFID 756 765 By similarity.
DISULFID 770 780 By similarity.
DISULFID 774 785 By similarity.
DISULFID 787 796 By similarity.
DISULFID 810 820 By similarity.
DISULFID 814 829 By similarity.
DISULFID 831 840 By similarity.
Amino Acid Sequence for TEN2_HUMAN » Teneurin-2
MDVKDRRHRS LTRGRCGKEC RYTSSSLDSE DCRVPTQKSY SSSETLKAYD HDSRMHYGNR VTDLVHRESD EFSRQGTNFT LAELGICEPS PHRSGYCSDM GILHQGYSLS TGSDADSDTE GGMSPEHAIR LWGRGIKSRR SSGLSSRENS ALTLTDSDNE NKSDDDNGRP IPPTSSSSLL PSAQLPSSHN PPPVSCQMPL LDSNTSHQIM DTNPDEEFSP NSYLLRACSG PQQASSSGPP NHHSQSTLRP PLPPPHNHTL SHHHSSANSL NRNSLTNRRS QIHAPAPAPN DLATTPESVQ LQDSWVLNSN VPLETRHFLF KTSSGSTPLF SSSSPGYPLT SGTVYTPPPR LLPRNTFSRK AFKLKKPSKY CSWKCAALSA IAAALLLAIL LAYFIAMHLL GLNWQLQPAD GHTFNNGVRT GLPGNDDVAT VPSGGKVPWS LKNSSIDSGE AEVGRRVTQE VPPGVFWRSQ IHISQPQFLK FNISLGKDAL FGVYIRRGLP PSHAQYDFME RLDGKEKWSV VESPRERRSI QTLVQNEAVF VQYLDVGLWH LAFYNDGKDK EMVSFNTVVL DSVQDCPRNC HGNGECVSGL CHCFPGFLGA DCAKAACPVL CSGNGQYSKG TCQCYSGWKG AECDVPMNQC IDPSCGGHGS CIDGNCVCSA GYKGEHCEEV DCLDPTCSSH GVCVNGECLC SPGWGGLNCE LARVQCPDQC SGHGTYLPDT GLCSCDPNWM GPDCSVEVCS VDCGTHGVCI GGACRCEEGW TGAACDQRVC HPRCIEHGTC KDGKCECREG WNGEHCTIGR QTAGTETDGC PDLCNGNGRC TLGQNSWQCV CQTGWRGPGC NVAMETSCAD NKDNEGDGLV DCLDPDCCLQ SACQNSLLCR GSRDPLDIIQ QGQTDWPAVK SFYDRIKLLA GKDSTHIIPG ENPFNSSLVS LIRGQVVTTD GTPLVGVNVS FVKYPKYGYT ITRQDGTFDL IANGGASLTL HFERAPFMSQ ERTVWLPWNS FYAMDTLVMK TEENSIPSCD LSGFVRPDPI IISSPLSTFF SAAPGQNPIV PETQVLHEEI ELPGSNVKLR YLSSRTAGYK SLLKITMTQS TVPLNLIRVH LMVAVEGHLF QKSFQASPNL AYTFIWDKTD AYGQRVYGLS DAVVSVGFEY ETCPSLILWE KRTALLQGFE LDPSNLGGWS LDKHHILNVK SGILHKGTGE NQFLTQQPAI ITSIMGNGRR RSISCPSCNG LAEGNKLLAP VALAVGIDGS LYVGDFNYIR RIFPSRNVTS ILELRNKEFK HSNNPAHKYY LAVDPVSGSL YVSDTNSRRI YRVKSLSGTK DLAGNSEVVA GTGEQCLPFD EARCGDGGKA IDATLMSPRG IAVDKNGLMY FVDATMIRKV DQNGIISTLL GSNDLTAVRP LSCDSSMDVA QVRLEWPTDL AVNPMDNSLY VLENNVILRI TENHQVSIIA GRPMHCQVPG IDYSLSKLAI HSALESASAI AISHTGVLYI TETDEKKINR LRQVTTNGEI CLLAGAASDC DCKNDVNCNC YSGDDAYATD AILNSPSSLA VAPDGTIYIA DLGNIRIRAV SKNKPVLNAF NQYEAASPGE QELYVFNADG IHQYTVSLVT GEYLYNFTYS TDNDVTELID NNGNSLKIRR DSSGMPRHLL MPDNQIITLT VGTNGGLKVV STQNLELGLM TYDGNTGLLA TKSDETGWTT FYDYDHEGRL TNVTRPTGVV TSLHREMEKS ITIDIENSNR DDDVTVITNL SSVEASYTVV QDQVRNSYQL CNNGTLRVMY ANGMGISFHS EPHVLAGTIT PTIGRCNISL PMENGLNSIE WRLRKEQIKG KVTIFGRKLR VHGRNLLSID YDRNIRTEKI YDDHRKFTLR IIYDQVGRPF LWLPSSGLAA VNVSYFFNGR LAGLQRGAMS ERTDIDKQGR IVSRMFADGK VWSYSYLDKS MVLLLQSQRQ YIFEYDSSDR LLAVTMPSVA RHSMSTHTSI GYIRNIYNPP ESNASVIFDY SDDGRILKTS FLGTGRQVFY KYGKLSKLSE IVYDSTAVTF GYDETTGVLK MVNLQSGGFS CTIRYRKIGP LVDKQIYRFS EEGMVNARFD YTYHDNSFRI ASIKPVISET PLPVDLYRYD EISGKVEHFG KFGVIYYDIN QIITTAVMTL SKHFDTHGRI KEVQYEMFRS LMYWMTVQYD SMGRVIKREL KLGPYANTTK YTYDYDGDGQ LQSVAVNDRP TWRYSYDLNG NLHLLNPGNS VRLMPLRYDL RDRITRLGDV QYKIDDDGYL CQRGSDIFEY NSKGLLTRAY NKASGWSVQY RYDGVGRRAS YKTNLGHHLQ YFYSDLHNPT RITHVYNHSN SEITSLYYDL QGHLFAMESS SGEEYYVASD NTGTPLAVFS INGPMIKQLQ YTAYGEIYYD SNPDFQMVIG FHGGLYDPLT KLVHFTQRDY DVLAGRWTSP DYTMWKNVGK EPAPFNLYMF KSNNPLSSEL DLKNYVTDVK SWLVMFGFQL SNIIPGFPRA KMYFVPPPYE LSESQASENG QLITGVQQTT ERHNQAFMAL EGQVITKKLH ASIREKAGHW FATTTPIIGK GIMFAIKEGR VTTGVSSIAS EDSRKVASVL NNAYYLDKMH YSIEGKDTHY FVKIGSADGD LVTLGTTIGR KVLESGVNVT VSQPTLLVNG RTRRFTNIEF QYSTLLLSIR YGLTPDTLDE EKARVLDQAR QRALGTAWAK EQQKARDGRE GSRLWTEGEK QQLLSTGRVQ GYEGYYVLPV EQYPELADSS SNIQFLRQNE MGKR