TEFF2_HUMAN » Tomoregulin-2

TEFF2_HUMAN » Tomoregulin-2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TEFF2_HUMAN » Tomoregulin-2 » Transmembrane protein with EGF-like and two follistatin-like domains;TR-2;Hyperplastic polyposis protein 1;
Hydrophobic Thickness 37.2 ± 2.4 Å
Tilt Angle 2 ± 3°
ΔGtransfer -39.2 kcal/mol
ΔGfold -17.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 314-342 (314-344)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 94-135, PDBID: 1LR7, Subunit A, Seq Identity:43%, Kazal-type serine protease inhibitor domain

AA: 186-227, PDBID: 2B0U, Subunit D, Seq Identity:43%, Kazal-type serine protease inhibitor domain

UniProt annotation for TEFF2_HUMAN » Tomoregulin-2
FUNCTION: May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation.

TISSUE SPECIFICITY: Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques (at protein level). Isoform 3 is expressed weakly in testis and at high levels in normal and cancerous prostate.

INDUCTION: Down-regulated in tumor cell lines in response to a high level of methylation in the 5" region. The CpG island methylation correlates with TMEFF2 silencing in tumor cell lines.

UniProt features for TEFF2_HUMAN » Tomoregulin-2
SIGNAL 1 40
CHAIN 41 374 Tomoregulin-2.
DOMAIN 85 137 Kazal-like 1.
DOMAIN 176 229 Kazal-like 2.
DOMAIN 261 301 EGF-like.
REGION 303 320 Required for shedding.
DISULFID 265 278 By similarity.
DISULFID 273 289 By similarity.
DISULFID 291 300 By similarity.
Amino Acid Sequence for TEFF2_HUMAN » Tomoregulin-2
MVLWESPRQC SSWTLCEGFC WLLLLPVMLL IVARPVKLAA FPTSLSDCQT PTGWNCSGYD DRENDLFLCD TNTCKFDGEC LRIGDTVTCV CQFKCNNDYV PVCGSNGESY QNECYLRQAA CKQQSEILVV SEGSCATDAG SGSGDGVHEG SGETSQKETS TCDICQFGAE CDEDAEDVWC VCNIDCSQTN FNPLCASDGK SYDNACQIKE ASCQKQEKIE VMSLGRCQDN TTTTTKSEDG HYARTDYAEN ANKLEESARE HHIPCPEHYN GFCMHGKCEH SINMQEPSCR CDAGYTGQHC EKKDYSVLYV VPGPVRFQYV LIAAVIGTIQ IAVICVVVLC ITRKCPRSNR IHRQKQNTGH YSSDNTTRAS TRLI