TEFF1_HUMAN » Tomoregulin-1

TEFF1_HUMAN » Tomoregulin-1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TEFF1_HUMAN » Tomoregulin-1 » TR-1; H7365;Transmembrane protein with EGF-like and one follistatin-like domain;
Hydrophobic Thickness 37.6 ± 4.2 Å
Tilt Angle 23 ± 5°
ΔGtransfer -23.6 kcal/mol
ΔGfold -22.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 327-352 (323-354)
Pathways none
PDB none
OPM none
Complexes none
Interactions

PTPRJ, Complex: TEFF1:PTPRJ

Domains

AA: 98-143, PDBID: 1LR7, Subunit A, Seq Identity:42%, Kazal-type serine protease inhibitor domain

AA: 194-235, PDBID: 1TBQ, Subunit S, Seq Identity:37%, Kazal-type serine protease inhibitor domain

UniProt annotation for TEFF1_HUMAN » Tomoregulin-1
FUNCTION: May inhibit NODAL and BMP signaling during neural patterning (By similarity). May be a tumor suppressor in brain cancers.

SUBUNIT: May interact with ST14.

TISSUE SPECIFICITY: Expressed predominantly in brain, and at lower levels in heart, placenta and skeletal muscle. Down-regulated in brain tumors as compared to control brain tissues.

UniProt features for TEFF1_HUMAN » Tomoregulin-1
SIGNAL 1 39 Potential.
CHAIN 40 380 Tomoregulin-1.
DOMAIN 93 145 Kazal-like 1.
DOMAIN 184 237 Kazal-like 2.
DOMAIN 271 311 EGF-like.
DISULFID 275 288 By similarity.
DISULFID 283 299 By similarity.
DISULFID 301 310 By similarity.
Amino Acid Sequence for TEFF1_HUMAN » Tomoregulin-1
MGAAAAEAPL RLPAAPPLAF CCYTSVLLLF AFSLPGSRAS NQPPGGGGGS GGDCPGGKGK SINCSELNVR ESDVRVCDES SCKYGGVCKE DGDGLKCACQ FQCHTNYIPV CGSNGDTYQN ECFLRRAACK HQKEITVIAR GPCYSDNGSG SGEGEEEGSG AEVHRKHSKC GPCKYKAECD EDAENVGCVC NIDCSGYSFN PVCASDGSSY NNPCFVREAS CIKQEQIDIR HLGHCTDTDD TSLLGKKDDG LQYRPDVKDA SDQREDVYIG NHMPCPENLN GYCIHGKCEF IYSTQKASCR CESGYTGQHC EKTDFSILYV VPSRQKLTHV LIAAIIGAVQ IAIIVAIVMC ITRKCPKNNR GRRQKQNLGH FTSDTSSRMV