TDR_ARATH » Leucine-rich repeat receptor-like protein kinase TDR

TDR_ARATH » Leucine-rich repeat receptor-like protein kinase TDR
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TDR_ARATH » Leucine-rich repeat receptor-like protein kinase TDR » Protein PHLOEM INTERCALATED WITH XYLEM;Tracheary element differentiation inhibitory factor receptor;AtTDR; TDIF receptor;
Hydrophobic Thickness 29.6 ± 2.6 Å
Tilt Angle 0 ± 3°
ΔGtransfer -44.1 kcal/mol
ΔGfold -19.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 651-678 (647-682)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 33-77, PDBID: 4MN8, Subunit A, Seq Identity:32%, Leucine rich repeat N-terminal domain

AA: 82-141, PDBID: 4MN8, Subunit A, Seq Identity:39%, Leucine rich repeat

AA: 250-272, PDBID: 4MN8, Subunit A, Seq Identity:45%, Leucine Rich Repeat

AA: 719-995, PDBID: 3TL8, Subunit A, Seq Identity:31%, Protein kinase domain

UniProt annotation for TDR_ARATH » Leucine-rich repeat receptor-like protein kinase TDR
FUNCTION: Acts with CLE41p and CLE44p peptides as a ligand- receptor pair in a signal transduction pathway involved in the regulation of procambium maintenance and polarity during vascular- tissue development. Mediates repression of tracheary element differentiation and the promotion of procambial cells formation and polar division adjacent to phloem cells in the veins.

CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.

SUBUNIT: Interacts specifically with the mature peptides CLE41p and CLE44p.

TISSUE SPECIFICITY: Widely expressed along the vascular strands. In roots and hypocotyls, confined to procambial cells.

UniProt features for TDR_ARATH » Leucine-rich repeat receptor-like protein kinase TDR
SIGNAL 1 29 Potential.
CHAIN 30 1041 Leucine-rich repeat receptor-like protein kinase TDR.
REPEAT 80 104 LRR 1.
REPEAT 105 128 LRR 2.
REPEAT 130 152 LRR 3.
REPEAT 154 176 LRR 4.
REPEAT 177 199 LRR 5.
REPEAT 200 224 LRR 6.
REPEAT 225 248 LRR 7.
REPEAT 250 272 LRR 8.
REPEAT 273 296 LRR 9.
REPEAT 297 319 LRR 10.
REPEAT 321 344 LRR 11.
REPEAT 345 368 LRR 12.
REPEAT 369 392 LRR 13.
REPEAT 394 416 LRR 14.
REPEAT 418 439 LRR 15.
REPEAT 440 464 LRR 16.
REPEAT 466 488 LRR 17.
REPEAT 511 535 LRR 18.
REPEAT 536 558 LRR 19.
REPEAT 559 583 LRR 20.
REPEAT 585 607 LRR 21.
DOMAIN 719 1001 Protein kinase.
ACT_SITE 852 852 Proton acceptor (By similarity).
Amino Acid Sequence for TDR_ARATH » Leucine-rich repeat receptor-like protein kinase TDR
MKKKNISPSL VLHPLLLLLL PFFAFNSLAL KFSPQLLSLL SLKTSLSGPP SAFQDWKVPV NGQNDAVWCS WSGVVCDNVT AQVISLDLSH RNLSGRIPIQ IRYLSSLLYL NLSGNSLEGS FPTSIFDLTK LTTLDISRNS FDSSFPPGIS KLKFLKVFNA FSNNFEGLLP SDVSRLRFLE ELNFGGSYFE GEIPAAYGGL QRLKFIHLAG NVLGGKLPPR LGLLTELQHM EIGYNHFNGN IPSEFALLSN LKYFDVSNCS LSGSLPQELG NLSNLETLFL FQNGFTGEIP ESYSNLKSLK LLDFSSNQLS GSIPSGFSTL KNLTWLSLIS NNLSGEVPEG IGELPELTTL FLWNNNFTGV LPHKLGSNGK LETMDVSNNS FTGTIPSSLC HGNKLYKLIL FSNMFEGELP KSLTRCESLW RFRSQNNRLN GTIPIGFGSL RNLTFVDLSN NRFTDQIPAD FATAPVLQYL NLSTNFFHRK LPENIWKAPN LQIFSASFSN LIGEIPNYVG CKSFYRIELQ GNSLNGTIPW DIGHCEKLLC LNLSQNHLNG IIPWEISTLP SIADVDLSHN LLTGTIPSDF GSSKTITTFN VSYNQLIGPI PSGSFAHLNP SFFSSNEGLC GDLVGKPCNS DRFNAGNADI DGHHKEERPK KTAGAIVWIL AAAIGVGFFV LVAATRCFQK SYGNRVDGGG RNGGDIGPWK LTAFQRLNFT ADDVVECLSK TDNILGMGST GTVYKAEMPN GEIIAVKKLW GKNKENGKIR RRKSGVLAEV DVLGNVRHRN IVRLLGCCTN RDCTMLLYEY MPNGSLDDLL HGGDKTMTAA AEWTALYQIA IGVAQGICYL HHDCDPVIVH RDLKPSNILL DADFEARVAD FGVAKLIQTD ESMSVVAGSY GYIAPEYAYT LQVDKKSDIY SYGVILLEII TGKRSVEPEF GEGNSIVDWV RSKLKTKEDV EEVLDKSMGR SCSLIREEMK QMLRIALLCT SRSPTDRPPM RDVLLILQEA KPKRKTVGDN VIVVGDVNDV NFEDVCSVDV GHDVKCQRIG V