TCA_HUMAN » T-cell receptor alpha chain C region

TCA_HUMAN » T-cell receptor alpha chain C region
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TCA_HUMAN » T-cell receptor alpha chain C region »
Hydrophobic Thickness 30.0 ± 1.6 Å
Tilt Angle 13 ± 2°
ΔGtransfer -16.3 kcal/mol
ΔGfold -10.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 118-137 (118-137)
Pathways

Immune System (Reactome)

PDB 3skn (A/C/E/G=1-95), 3qjf (A/C=1-95), 2ial (A/C=1-95), 3dx9 (A/C=3-92), 2eyt (A/C=3-95), 3qeu (A/D=1-93), 4c56 (A/G=2-95), 2cdf (A=1-80), 2cdg (A=1-80), 3gsn (A=1-91), 2bnu (A=1-91), 4onh (A=1-95), 2xna (A=1-95), 2xn9 (A=1-95), 4g8e (A=2-92), 4g8f (A=2-95), 2pyf (A=3-93), 2eyr (A=3-95), 2eys (A=3-95), 3o6f (C/G=1-92), 3tvm (C/G=1-95), 2po6 (C/G=3-92), 3sdd (C=1-95), 3arg (C=1-95), 3arb (C=1-95), 3ard (C=1-95), 3are (C=1-95), 3arf (C=1-95), 3tn0 (C=1-95), 3he7 (C=1-95), 3sdc (C=1-95), 3sda (C=1-95), 2iam (C=1-95), 4apq (C=1-95), 3o8x (C=1-95), 4irs (C=1-95), 3o9w (C=1-95), 3scm (C=1-95), 3qux (C=1-95), 3qib (C=1-95), 3t0e (C=1-96), 3kxf (D/G/M/N=1-91), 3sjv (D/I/N/S=1-95), 2ian (D/I/N/S=1-95), 2nx5 (D/I/N/T=1-79), 2ak4 (D/I/N/T=1-95), 3dxa (D/I/N=3-93), 3ffc (D/I=1-91), 2vlr (D/I=1-91), 3kpr (D/I=1-91), 2f54 (D/K=3-93), 2p5e (D=1-81), 2pye (D=1-81), 3hg1 (D=1-87), 4jfd (D=1-88), 3qeq (D=1-88), 4jfe (D=1-89), 4jff (D=1-89), 3qdm (D=1-89), 4prp (D=1-91), 4jrx (D=1-91), 4jry (D=1-91), 4pri (D=1-91), 3qdg (D=1-91), 1mi5 (D=1-91), 1qrn (D=1-91), 1qsf (D=1-91), 2bnq (D=1-91), 2bnr (D=1-91), 2esv (D=1-91), 2gj6 (D=1-91), 2vlj (D=1-91), 2vlk (D=1-91), 2vlm (D=1-91), 3d39 (D=1-91), 3kps (D=1-91), 3qdj (D=1-91), 3pwp (D=1-91), 3o4l (D=1-92), 4jfh (D=1-92), 4prh (D=1-95), 1kgc (D=1-95), 1oga (D=1-97), 1fyt (D=1-99), 1j8h (D=1-99), 1ymm (D=2-96), 2f53 (D=3-79), 2p5w (D=3-79), 3sdx (E/G=1-92), 1zgl (M/Q/S/U=1-96)
OPM none
Complexes

2B14:TRBC2:DRA:TCA:CD4_HUMAN

MBP:DRB5:DRA:TCA:TRBC1_HUMAN

DRA:2B11:TCA:TRBC1:HEMA_HUMAN

DRA:2B11:TCA:TRBC1:TPIS_HUMAN

HEMA:ETXH:DRA:2B11:TCA:TRBC1_HUMAN

2B14:DRA:TCA:TRBC1:HEMA_HUMAN

MBP:2B1F:DRA:TCA:TRBC1_HUMAN

TRBC2:DRA:2B11:TCA:ETXB:HEMA_HUMAN

2B14:TRBC2:DRA:TCA_HUMAN

CD1D1:TCA:TRBC1:B2MG_HUMAN

TCA:TRBC1:CD1D:B2MG_HUMAN

CD1D1:TRBC2:TCA:B2MG_HUMAN

TCA:CD1D:B2MG_HUMAN

TRBC2:TCA_HUMAN

TCA:TRBC1_HUMAN

CTG1B:TCA:TRBC1:1A02:B2MG_HUMAN

M1:TCA:TRBC1:1A02:B2MG_HUMAN

ICP27:Q8WLS4:TCA:TRBC1:1A02:B2MG_HUMAN

CTG1B:TRBC2:TCA:1A02:B2MG_HUMAN

EMC7:TCA:1A02:B2MG_HUMAN

TVB5:EMC7:TCA:1A02:B2MG_HUMAN

TCA:TRBC1:MAR1:1A02:B2MG_HUMAN

TCA:TRBC1:1A02:B2MG_HUMAN

EBNA3:TCA:TRBC1:1B08:B2MG_HUMAN

TCA:TRBC1:1B08:B2MG_HUMAN

BZLF1:TCA:TRBC1:1B35:B2MG_HUMAN

BZLF1:TRBC2:TCA:1B35:B2MG_HUMAN

1B44:TCA:TRBC1:B2MG_HUMAN

EBNA6:1B44:TCA:TRBC1:B2MG_HUMAN

BZLF1:C5MK56:TCA:TRBC1:B2MG_HUMAN

C5MK56:TCA:TRBC1:EBNA1:B2MG_HUMAN

UL40:HLAE:TCA:TRBC1:B2MG_HUMAN

TCA:TRBC1_HUMAN

ETXH:TCA:TRBC1_HUMAN

Q8WLS4:TCA:TRBC1:MAR1:B2MG_HUMAN

Interactions

1A02, Complex: 1A02:B2MG:TCA, PDBID: 1oga

1B08, Complex: 1B08:B2MG:TCA, PDBID: 1mi5

1B35, Complex: 1B35:B2MG:TCA, PDBID: 2ak4

1B44, Complex: 1B44:B2MG:TCA, PDBID: 3dxa

2B11, Complex: 2B11:2DRA:TCA, PDBID: 2iam

CD1D, Complex: B2MG:CD1D:TCA, PDBID: 2po6

EMC7, Complex: TVB5:EMC7:TCA:1A02:B2MG, PDBID: 1LP9

HLAE, Complex: B2MG:HLAE:TCA, PDBID: 2esv

TRBC1, Complex: DRA:2B11:TCA:TRBC1:HEMA, PDBID: 1fyt, PubMed

TRBC2, Complex: CTG1B:TRBC2:TCA:1A02:B2MG, PDBID: 2BNQ

Domains

AA: 8-91, PDBID: 1FYT, Subunit D, Seq Identity:100%, Domain of unknown function (DUF1968)

UniProt annotation for TCA_HUMAN » T-cell receptor alpha chain C region
DISEASE: Immunodeficiency 7 (IMD7) OMIM: A primary immunodeficiency disorder manifesting with recurrent respiratory infections, candidiasis, diarrhea, and failure to thrive. Patients show a clear predisposition to herpes viral infections, and features of immune dysregulation, including hypereosinophilia, vitiligo, and alopecia areata. Other features include lymphadenopathy and hepatosplenomegaly. CD3+ T-cells express TCR- gamma/delta, but little or no TCR-alpha/beta. mutations affecting the gene represented in this entry.

MISCELLANEOUS: This clone was isolated from a human leukemic T- cell line, Jurkat.

MISCELLANEOUS: This alpha chain C region shows sequence homology to its beta chain counterpart.

MISCELLANEOUS: The gene corresponding to this mRNA is rearranged specifically in T-cells; its organization is similar to an Ig gene, with V, D, J, and C regions.

UniProt features for TCA_HUMAN » T-cell receptor alpha chain C region
CHAIN <1 142 T-cell receptor alpha chain C region.
REGION 1 117 C region.
DISULFID 24 74
Amino Acid Sequence for TCA_HUMAN » T-cell receptor alpha chain C region
PNIQNPDPAV YQLRDSKSSD KSVCLFTDFD SQTNVSQSKD SDVYITDKTV LDMRSMDFKS NSAVAWSNKS DFACANAFNN SIIPEDTFFP SPESSCDVKL VEKSFETDTN LNFQNLSVIG FRILLLKVAG FNLLMTLRLW SS