TATB_ECOLI » Sec-independent protein translocase protein TatB

TATB_ECOLI » Sec-independent protein translocase protein TatB
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Topology in Bacterial Gram-negative inner membrane
Topologyextracellular side
cytoplasmic side
TATB_ECOLI » Sec-independent protein translocase protein TatB »
Hydrophobic Thickness 31.6 ± 3.6 Å
Tilt Angle 19 ± 10°
ΔGtransfer -21.5 kcal/mol
ΔGfold -8.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 3-23 (3-25)
Pathways

Bacterial secretion system (KEGG)

Protein export (KEGG)

PDB none
OPM none
Complexes none
Interactions

TATA, Complex: TATA:TATB

Domains none
UniProt annotation for TATB_ECOLI » Sec-independent protein translocase protein TatB
FUNCTION: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.

SUBUNIT: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon. A complex containing only TatA and TatB has also been identified. It could be either an assembly intermediate or a disassembly intermediate generated during translocation activity. Each of TatA, TatB and TatC are able to interact in pairs without the third partner; TatB also forms homooligomers. Interacts with the signal sequence of DmsA and DmsD.

INDUCTION: Constitutively expressed.

DOMAIN: The membrane-extrinsic domain forms parallel contacts with at least one other TatB protein.

UniProt features for TATB_ECOLI » Sec-independent protein translocase protein TatB
CHAIN 1 171 Sec-independent protein translocase protein TatB.
Amino Acid Sequence for TATB_ECOLI » Sec-independent protein translocase protein TatB
MFDIGFSELL LVFIIGLVVL GPQRLPVAVK TVAGWIRALR SLATTVQNEL TQELKLQEFQ DSLKKVEKAS LTNLTPELKA SMDELRQAAE SMKRSYVAND PEKASDEAHT IHNPVVKDNE AAHEGVTPAA AQTQASSPEQ KPETTPEPVV KPAADAEPKT AAPSPSSSDK P