TACT_HUMAN » T-cell surface protein tactile

TACT_HUMAN » T-cell surface protein tactile
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TACT_HUMAN » T-cell surface protein tactile » Cell surface antigen CD96;T cell-activated increased late expression protein;
Hydrophobic Thickness 33.6 ± 2.0 Å
Tilt Angle 0 ± 2°
ΔGtransfer -37.5 kcal/mol
ΔGfold -17.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 521-542 (521-553)
Pathways

Immune System (Reactome)

PDB none
OPM none
Complexes none
Interactions

PVR, Complex: TACT:PVR, PubMed

Domains

AA: 25-136, Immunoglobulin domain

AA: 268-359, Immunoglobulin domain

UniProt annotation for TACT_HUMAN » T-cell surface protein tactile
FUNCTION: May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation.

SUBUNIT: Homodimer; disulfide-linked. Interacts with PVR.

TISSUE SPECIFICITY: Expressed on normal T-cell lines and clones, and some transformed T-cells, but no other cultured cell lines tested. It is expressed at very low levels on activated B-cells.

DEVELOPMENTAL STAGE: Expressed at low levels on peripheral T-cells and is strongly up-regulated after activation, peaking 6 to 9 days after the activating stimulus.

DISEASE: C syndrome (CSYN) OMIM: A syndrome characterized by trigonocephaly, severe mental retardation, hypotonia, variable cardiac defects, redundant skin, and dysmorphic facial features, including upslanted palpebral fissures, epicanthal folds, depressed nasal bridge, and low-set, posteriorly rotated ears. mutations affecting the gene represented in this entry. A chromosomal aberration involving CD96 has been found in a patient with C syndrome. Translocation t(3;18)(q13.13;q12.1). CD96 gene was located at the 3q13.13 breakpoint. Precise structural analysis around the breakpoint showed that the gene was disrupted by the translocation in exon 5, probably leading to premature termination or loss of expression of CD96 protein. No gene was detected at the chromosome 18 breakpoint.

UniProt features for TACT_HUMAN » T-cell surface protein tactile
SIGNAL 1 21 Potential.
CHAIN 22 585 T-cell surface protein tactile.
DOMAIN 38 125 Ig-like V-type 1.
DOMAIN 156 238 Ig-like V-type 2.
DOMAIN 269 375 Ig-like C2-type.
DISULFID 45 118 Probable.
DISULFID 163 247 Probable.
DISULFID 290 355 Probable.
Amino Acid Sequence for TACT_HUMAN » T-cell surface protein tactile
MEKKWKYCAV YYIIQIHFVK GVWEKTVNTE ENVYATLGSD VNLTCQTQTV GFFVQMQWSK VTNKIDLIAV YHPQYGFYCA YGRPCESLVT FTETPENGSK WTLHLRNMSC SVSGRYECML VLYPEGIQTK IYNLLIQTHV TADEWNSNHT IEIEINQTLE IPCFQNSSSK ISSEFTYAWS VENSSTDSWV LLSKGIKEDN GTQETLISQN HLISNSTLLK DRVKLGTDYR LHLSPVQIFD DGRKFSCHIR VGPNKILRSS TTVKVFAKPE IPVIVENNST DVLVERRFTC LLKNVFPKAN ITWFIDGSFL HDEKEGIYIT NEERKGKDGF LELKSVLTRV HSNKPAQSDN LTIWCMALSP VPGNKVWNIS SEKITFLLGS EISSTDPPLS VTESTLDTQP SPASSVSPAR YPATSSVTLV DVSALRPNTT PQPSNSSMTT RGFNYPWTSS GTDTKKSVSR IPSETYSSSP SGAGSTLHDN VFTSTARAFS EVPTTANGST KTNHVHITGI VVNKPKDGMS WPVIVAALLF CCMILFGLGV RKWCQYQKEI MERPPPFKPP PPPIKYTCIQ EPNESDLPYH EMETL