TACD2_HUMAN » Tumor-associated calcium signal transducer 2

TACD2_HUMAN » Tumor-associated calcium signal transducer 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TACD2_HUMAN » Tumor-associated calcium signal transducer 2 » Cell surface glycoprotein Trop-2;Membrane component chromosome 1 surface marker 1;Pancreatic carcinoma marker protein GA733-1;
Hydrophobic Thickness 37.2 ± 4.8 Å
Tilt Angle 29 ± 1°
ΔGtransfer -33.9 kcal/mol
ΔGfold -27.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 273-298 (268-303)
Pathways none
PDB 2mae (298-323)
OPM 2mae
Complexes none
Interactions none
Domains

AA: 73-145, PDBID: 4MZV, Subunit A, Seq Identity:53%, Thyroglobulin type-1 repeat

UniProt annotation for TACD2_HUMAN » Tumor-associated calcium signal transducer 2
FUNCTION: May function as a growth factor receptor.

TISSUE SPECIFICITY: Placenta, pancreatic carcinoma cell lines.

DISEASE: Corneal dystrophy, gelatinous drop-like (GDLD) OMIM: A form of lattice corneal dystrophy, a class of inherited stromal amyloidoses characterized by pathognomonic branching lattice figures in the cornea. GDLD is an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness. Clinical manifestations, which appear in the first decade of life, include blurred vision, photophobia, and foreign-body sensation. By the third decade, raised, yellowish- gray, gelatinous masses severely impair visual acuity. mutations affecting the gene represented in this entry.

UniProt features for TACD2_HUMAN » Tumor-associated calcium signal transducer 2
SIGNAL 1 26 Potential.
CHAIN 27 323 Tumor-associated calcium signal transducer 2.
DOMAIN 70 145 Thyroglobulin type-1.
DISULFID 73 108 By similarity.
DISULFID 119 125 By similarity.
DISULFID 127 145 By similarity.
Amino Acid Sequence for TACD2_HUMAN » Tumor-associated calcium signal transducer 2
MARGPGLAPP PLRLPLLLLV LAAVTGHTAA QDNCTCPTNK MTVCSPDGPG GRCQCRALGS GMAVDCSTLT SKCLLLKARM SAPKNARTLV RPSEHALVDN DGLYDPDCDP EGRFKARQCN QTSVCWCVNS VGVRRTDKGD LSLRCDELVR THHILIDLRH RPTAGAFNHS DLDAELRRLF RERYRLHPKF VAAVHYEQPT IQIELRQNTS QKAAGDVDIG DAAYYFERDI KGESLFQGRG GLDLRVRGEP LQVERTLIYY LDEIPPKFSM KRLTAGLIAV IVVVVVALVA GMAVLVITNR RKSGKYKKVE IKELGELRKE PSL