T3JAM_HUMAN » TRAF3-interacting JNK-activating modulator

T3JAM_HUMAN » TRAF3-interacting JNK-activating modulator
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
T3JAM_HUMAN » TRAF3-interacting JNK-activating modulator » TRAF3-interacting protein 3;
Hydrophobic Thickness 28.8 ± 2.7 Å
Tilt Angle 14 ± 2°
ΔGtransfer -20.6 kcal/mol
ΔGfold -14.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 527-545 (527-546)
Pathways none
PDB none
OPM none
Complexes none
Interactions

EMD, Complex: EMD:T3JAM

FATE1, Complex: FATE1:T3JAM

KASH5, Complex: KASH5:T3JAM

Domains none
UniProt annotation for T3JAM_HUMAN » TRAF3-interacting JNK-activating modulator
FUNCTION: May function as an adapter molecule that regulates TRAF3-mediated JNK activation.

SUBUNIT: Binds to the isoleucine zipper of TRAF3 via its coiled- coil domain.

UniProt features for T3JAM_HUMAN » TRAF3-interacting JNK-activating modulator
CHAIN 1 551 TRAF3-interacting JNK-activating modulator.
COILED 240 436 Potential.
COILED 464 506 Potential.
CROSSLNK 267 267 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin).
Amino Acid Sequence for T3JAM_HUMAN » TRAF3-interacting JNK-activating modulator
MISPDPRPSP GLARWAESYE AKCERRQEIR ESRRCRPNVT TCRQVGKTLR IQQREQLQRA RLQQFFRRRN LELEEKGKAQ HPQAREQGPS RRPGQVTVLK EPLSCARRIS SPREQVTGTS SEVFPAQHPP PSGICRDLSD HLSSQAGGLP PQDTPIKKPP KHHRGTQTKA EGPTIKNDAS QQTNYGVAVL DKEIIQLSDY LKEALQRELV LKQKMVILQD LLSTLIQASD SSWKGQLNED KLKGKLRSLE NQLYTCTQKY SPWGMKKVLL EMEDQKNSYE QKAKESLQKV LEEKMNAEQQ LQSTQRSLAL AEQKCEEWRS QYEALKEDWR TLGTQHRELE SQLHVLQSKL QGADSRDLQM NQALRFLENE HQQLQAKIEC LQGDRDLCSL DTQDLQDQLK RSEAEKLTLV TRVQQLQGLL QNQSLQLQEQ EKLLTKKDQA LPVWSPKSFP NEVEPEGTGK EKDWDLRDQL QKKTLQLQAK EKECRELHSE LDNLSDEYLS CLRKLQHCRE ELNQSQQLPP RRQCGRWLPV LMVVIAAALA VFLANKDNLM I