T131L_HUMAN » Transmembrane protein 131-like

T131L_HUMAN » Transmembrane protein 131-like
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
T131L_HUMAN » Transmembrane protein 131-like »
Hydrophobic Thickness 34.0 ± 3.4 Å
Tilt Angle 43 ± 1°
ΔGtransfer -32.1 kcal/mol
ΔGfold -19.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 869-898 (866-901)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 91-174, Transmembrane protein 131-like

UniProt annotation for T131L_HUMAN » Transmembrane protein 131-like
FUNCTION: Isoform 1: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation.

TISSUE SPECIFICITY: Expressed in thymocytes.

DEVELOPMENTAL STAGE: During intrathymic development, transcript levels strongly increase from pro-DN1 thymocytes to DN3a cells, in which they peak, and drop immediately after beta-selection in their DN3b successors. The subcellular location of the protein also varies, from punctate cytoplasmic structures in DN1 and DN2 cells to large crescent-shaped membrane structures in DN3 cells, which preferentially localize in cell-to-cell contact zones.

UniProt features for T131L_HUMAN » Transmembrane protein 131-like
SIGNAL 1 40 Potential.
CHAIN 41 1609 Transmembrane protein 131-like.
Amino Acid Sequence for T131L_HUMAN » Transmembrane protein 131-like
MAGLRRPQPG CYCRTAAAVN LLLGVFQVLL PCCRPGGAQG QAIEPLPNVV ELWQAEEGEL LLPTQGDSEE GLEEPSQEQS FSDKLFSGKG LHFQPSVLDF GIQFLGHPVA KILHAYNPSR DSEVVVNSVF AAAGHFHVPP VPCRVIPAMG KTSFRIIFLP TEEGSIESSL FINTSSYGVL SYHVSGIGTR RISTEGSAKQ LPNAYFLLPK VQSIQLSQMQ AETTNTSLLQ VQLECSLHNK VCQQLKGCYL ESDDVLRLQM SIMVTMENFS KEFEENTQHL LDHLSIVYVA TDESETSDDS AVNMYILHSG NSLIWIQDIR HFSQRDALSL QFEPVLLPTS TTNFTKIASF TCKATSCDSG IIEDVKKTTH TPTLKACLFS SVAQGYFRMD SSATQFHIET HENTSGLWSI WYRNHFDRSV VLNDVFLSKE TKHMLKILNF TGPLFLPPGC WNIFSLKLAV KDIAINLFTN VFLTTNIGAI FAIPLQIYSA PTKEGSLGFE VIAHCGMHYF MGKSKAGNPN WNGSLSLDQS TWNVDSELAN KLYERWKKYK NGDVCKRNVL GTTRFAHLKK SKESESFVFF LPRLIAEPGL MLNFSATALR SRMIKYFVVQ NPSSWPVSLQ LLPLSLYPKP EALVHLLHRW FGTDMQMINF TTGEFQLTEA CPYLGTHSEE SRFGILHLHL QPLEMKRVGV VFTPADYGKV TSLILIRNNL TVIDMIGVEG FGARELLKVG GRLPGAGGSL RFKVPESTLM DCRRQLKDSK QILSITKNFK VENIGPLPIT VSSLKINGYN CQGYGFEVLD CHQFSLDPNT SRDISIVFTP DFTSSWVIRD LSLVTAADLE FRFTLNVTLP HHLLPLCADV VPGPSWEESF WRLTVFFVSL SLLGVILIAF QQAQYILMEF MKTRQRQNAS SSSQQNNGPM DVISPHSYKS NCKNFLDTYG PSDKGRGKNC LPVNTPQSRI QNAAKRSPAT YGHSQKKHKC SVYYSKHKTS TAAASSTSTT TEEKQTSPLG SSLPAAKEDI CTDAMRENWI SLRYASGINV NLQKNLTLPK NLLNKEENTL KNTIVFSNPS SECSMKEGIQ TCMFPKETDI KTSENTAEFK ERELCPLKTS KKLPENHLPR NSPQYHQPDL PEISRKNNGN NQQVPVKNEV DHCENLKKVD TKPSSEKKIH KTSREDMFSE KQDIPFVEQE DPYRKKKLQE KREGNLQNLN WSKSRTCRKN KKRGVAPVSR PPEQSDLKLV CSDFERSELS SDINVRSWCI QESTREVCKA DAEIASSLPA AQREAEGYYQ KPEKKCVDKF CSDSSSDCGS SSGSVRASRG SWGSWSSTSS SDGDKKPMVD AQHFLPAGDS VSQNDFPSEA PISLNLSHNI CNPMTVNSLP QYAEPSCPSL PAGPTGVEED KGLYSPGDLW PTPPVCVTSS LNCTLENGVP CVIQESAPVH NSFIDWSATC EGQFSSAYCP LELNDYNAFP EENMNYANGF PCPADVQTDF IDHNSQSTWN TPPNMPAAWG HASFISSPPY LTSTRSLSPM SGLFGSIWAP QSDVYENCCP INPTTEHSTH MENQAVVCKE YYPGFNPFRA YMNLDIWTTT ANRNANFPLS RDSSYCGNV