SYT9_HUMAN » Synaptotagmin-9

SYT9_HUMAN » Synaptotagmin-9
Magnify SYT9_HUMAN » Synaptotagmin-9Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Vesicle membrane
Topologyvesicle lumenal side
cytoplasmic side
SYT9_HUMAN » Synaptotagmin-9 » Synaptotagmin IX;SytIX;
Hydrophobic Thickness 39.2 ± 3.2 Å
Tilt Angle 0 ± 0°
ΔGtransfer -41.3 kcal/mol
ΔGfold -15.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 48-73 (48-75)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 235-333, PDBID: 1DQV, Subunit A, Seq Identity:70%, C2 domain

AA: 367-477, PDBID: 1DQV, Subunit A, Seq Identity:66%, C2 domain

UniProt annotation for SYT9_HUMAN » Synaptotagmin-9
FUNCTION: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.
UniProt features for SYT9_HUMAN » Synaptotagmin-9
CHAIN 1 491 Synaptotagmin-9.
DOMAIN 222 323 C2 1.
DOMAIN 354 457 C2 2.
Amino Acid Sequence for SYT9_HUMAN » Synaptotagmin-9
MPGARDALCH QALQLLAELC ARGALEHDSC QDFIYHLRDR ARPRLRDPDI SVSLLTLVVT ACGLALFGVS LFVSWKLCWV PWRERGLPSG SKDNNQEPLN YMDTETNEQE NSEDFLDPPT PCPDSSMKIS HTSPDIPLST QTGIQENCAH GVRVQRQVTE PTSSARHNSI RRQLNLSNPD FNIQQLQKQE QLTGIGRIKP ELYKQRSLDN DDGRRSNSKA CGKLNFILKY DCDLEQLIVK IHKAVNLPAK DFSGTSDPYV KIYLLPDRKT KHQTKVHRKT LNPVFDEVFL FPVPYNDLEA RKLHFSVYDF DRFSRHDLIG QVVVDHFLDL ADFPRECILW KDIEYVTNDN VDLGELMFSL CYLPTAGRLT ITIIKARNLK AMDITGASDP YVKVSLMCDG RRLKKRKTST KRNTLNPVYN EAIVFDVPPE NIDQIHLSIA VMDYDRVGHN EIIGVCQVGN EAERLGRDHW SEMLSYPRKP IAHWHSLVEK R