SYT8_HUMAN » Synaptotagmin-8

SYT8_HUMAN » Synaptotagmin-8
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Topology in Vesicle membrane
Topologyvesicle lumenal side
cytoplasmic side
SYT8_HUMAN » Synaptotagmin-8 » Synaptotagmin VIII;SytVIII;
Hydrophobic Thickness 33.8 ± 2.0 Å
Tilt Angle 1 ± 1°
ΔGtransfer -16.7 kcal/mol
ΔGfold -15.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 49-71 (45-80)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 132-235, PDBID: 1BYN, Subunit A, Seq Identity:44%, C2 domain

AA: 260-362, PDBID: 1K5W, Subunit A, Seq Identity:47%, C2 domain

UniProt annotation for SYT8_HUMAN » Synaptotagmin-8
FUNCTION: Isoform 4 may play a role in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Mediates Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. May mediate Ca(2+)-regulation of exocytosis in insulin secreted cells (By similarity).

SUBUNIT: Homodimer or homooligomer. Homodimerization and homooligomerization do not depend on Ca(2+). Interacts with SYNCRIP isoform 2 C-terminus. Binds inositol 1,3,4,5- tetrakisphosphate (IP4). Binds to AP2 in a Ca(2+)-independent manner. Interacts with STX1A, STX1B and STX2; the interaction is Ca(2+)-dependent (By similarity).

DOMAIN: The first C2 domain/C2A does not mediate Ca(2+)-dependent phospholipid binding.

DOMAIN: The second C2 domain/C2B is responsible for SYNCRIP and inositol 1,3,4,5-tetrakisphosphate (IP4)-binding.

UniProt features for SYT8_HUMAN » Synaptotagmin-8
CHAIN 1 401 Synaptotagmin-8.
DOMAIN 119 217 C2 1.
DOMAIN 247 346 C2 2.
Amino Acid Sequence for SYT8_HUMAN » Synaptotagmin-8
MLHLHGWQTM QGRKMGHPPV SPSAPAPAGT TAIPGLIPDL VAGTPGPRWA LIAGALAAGV LLVSCLLCAA CCCCRRHRKK PRDKESVGLG SARGTTTTHL VQPDVDGLES SPGDAQQWGR LQLSLEFDFG SQEVKGPAAQ DQRFCEFPER VTGEGQTPCP GWWGADRAGA LG