![]() | vesicle lumenal side |
cytoplasmic side |
SYT8_HUMAN » Synaptotagmin-8 » Synaptotagmin VIII;SytVIII; | |
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Hydrophobic Thickness | 33.8 ± 2.0 Å |
Tilt Angle | 1 ± 1° |
ΔGtransfer | -16.7 kcal/mol |
ΔGfold | -15.3 kcal/mol |
Links | UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC |
Topology | Out |
TM Segments | 49-71 (45-80) |
Pathways | none |
PDB | none |
OPM | none |
Complexes | none |
Interactions | none |
Domains | AA: 132-235, PDBID: 1BYN, Subunit A, Seq Identity:44%, C2 domain AA: 260-362, PDBID: 1K5W, Subunit A, Seq Identity:47%, C2 domain |
UniProt annotation for SYT8_HUMAN » Synaptotagmin-8 |
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FUNCTION: Isoform 4 may play a role in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Mediates Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. May mediate Ca(2+)-regulation of exocytosis in insulin secreted cells (By similarity). SUBUNIT: Homodimer or homooligomer. Homodimerization and homooligomerization do not depend on Ca(2+). Interacts with SYNCRIP isoform 2 C-terminus. Binds inositol 1,3,4,5- tetrakisphosphate (IP4). Binds to AP2 in a Ca(2+)-independent manner. Interacts with STX1A, STX1B and STX2; the interaction is Ca(2+)-dependent (By similarity). DOMAIN: The first C2 domain/C2A does not mediate Ca(2+)-dependent phospholipid binding. DOMAIN: The second C2 domain/C2B is responsible for SYNCRIP and inositol 1,3,4,5-tetrakisphosphate (IP4)-binding. |
UniProt features for SYT8_HUMAN » Synaptotagmin-8 |
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CHAIN 1 401 Synaptotagmin-8. DOMAIN 119 217 C2 1. DOMAIN 247 346 C2 2. |
Amino Acid Sequence for SYT8_HUMAN » Synaptotagmin-8 |
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MLHLHGWQTM QGRKMGHPPV SPSAPAPAGT TAIPGLIPDL VAGTPGPRWA LIAGALAAGV LLVSCLLCAA CCCCRRHRKK PRDKESVGLG SARGTTTTHL VQPDVDGLES SPGDAQQWGR LQLSLEFDFG SQEVKGPAAQ DQRFCEFPER VTGEGQTPCP GWWGADRAGA LG |