SYT7_HUMAN » Synaptotagmin-7

SYT7_HUMAN » Synaptotagmin-7
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Topology in Vesicle membrane
Topologyvesicle lumenal side
cytoplasmic side
SYT7_HUMAN » Synaptotagmin-7 » IPCA-7;Prostate cancer-associated protein 7;Synaptotagmin VII;SytVII;
Hydrophobic Thickness 32.8 ± 4.2 Å
Tilt Angle 25 ± 23°
ΔGtransfer -17.3 kcal/mol
ΔGfold -12.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 16-40 (15-45)
Pathways none
PDB 2d8k (132-259)
OPM 2d8k, 3n5a (MOUSE)
Complexes none
Interactions

STX1A, Complex: STX1A:SYT7, PubMed

STX2, Complex: SYT7:STX2, PubMed

STX3, Complex: SYT7:STX3, PubMed

STX4, Complex: SYT7:STX4, PubMed

Domains

AA: 150-257, PDBID: 2D8K, Subunit A, Seq Identity:100%, C2 domain

AA: 281-399, PDBID: 3N5A, Subunit A, Seq Identity:99%, C2 domain

UniProt annotation for SYT7_HUMAN » Synaptotagmin-7
FUNCTION: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.

SUBUNIT: Interacts with SYNCRIP isoform 3 C-terminus.

TISSUE SPECIFICITY: Expressed in a variety of adult and fetal tissues.

DOMAIN: The second C2 domain/C2B is responsible for SYNCRIP binding.

UniProt features for SYT7_HUMAN » Synaptotagmin-7
CHAIN 1 403 Synaptotagmin-7.
DOMAIN 137 239 C2 1.
DOMAIN 268 371 C2 2.
Amino Acid Sequence for SYT7_HUMAN » Synaptotagmin-7
MYRDPEAASP GAPSRDVLLV SAIITVSLSV TVVLCGLCHW CQRKLGKRYK NSLETVGTPD SGRGRSEKKA IKLPAGGKAV NTAPVPGQTP HDESDRRTEP RSSVSDLVNS LTSEMLMLSP GSEEDEAHEG CSRENLGRIQ FSVGYNFQES TLTVKIMKAQ ELPAKDFSGT SDPFVKIYLL PDKKHKLETK VKRKNLNPHW NETFLFEGFP YEKVVQRILY LQVLDYDRFS RNDPIGEVSI PLNKVDLTQM QTFWKDLKPC SDGSGSRGEL LLSLCYNPSA NSIIVNIIKA RNLKAMDIGG TSDPYVKVWL MYKDKRVEKK KTVTMKRNLN PIFNESFAFD IPTEKLRETT IIITVMDKDK LSRNDVIGKI YLSWKSGPGE VKHWKDMIAR PRQPVAQWHQ LKA