SYT6_HUMAN » Synaptotagmin-6

SYT6_HUMAN » Synaptotagmin-6
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Topology in Vesicle membrane
Topologyvesicle lumenal side
cytoplasmic side
SYT6_HUMAN » Synaptotagmin-6 » Synaptotagmin VI;SytVI;
Hydrophobic Thickness 36.8 ± 1.4 Å
Tilt Angle 2 ± 0°
ΔGtransfer -49.2 kcal/mol
ΔGfold -26.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 58-83 (56-83)
Pathways none
PDB none
OPM none
Complexes none
Interactions

A4, Complex: A4:SYT6, PubMed

Domains

AA: 244-352, PDBID: 1DQV, Subunit A, Seq Identity:70%, C2 domain

AA: 376-494, PDBID: 1DQV, Subunit A, Seq Identity:60%, C2 domain

UniProt annotation for SYT6_HUMAN » Synaptotagmin-6
FUNCTION: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)- regulation of exocytosis in acrosomal reaction in sperm (By similarity).

SUBUNIT: Homodimer (isoform 1). Isoform 1 forms heterodimers with SytIII, SytV and SytX. Interacts with STX1A, STX1B and STX2; the interaction is Ca(2+)-dependent. Isoform 2 is not able to form homodimer and heterodimers (By similarity).

UniProt features for SYT6_HUMAN » Synaptotagmin-6
CHAIN 1 510 Synaptotagmin-6.
DOMAIN 231 332 C2 1.
DOMAIN 363 466 C2 2.
REGION 482 510 Necessary for cell membrane association (isoform 2) (By similarity).
Amino Acid Sequence for SYT6_HUMAN » Synaptotagmin-6
MSGVWGAGGP RCQEALAVLA SLCRARPPPL GLDVETCRSF ELQPPERSPS AAGAGTSVSL LAVVVIVCGV ALVAVFLFLF WKLCWMPWRN KEASSPSSAN PPLEALQSPS FRGNMADKLK DPSTLGFLEA AVKISHTSPD IPAEVQMSVK EHIMRHTRLQ RQTTEPASST RHTSFKRHLP RQMHVSSVDY GNELPPAAEQ PTSIGRIKPE LYKQKSVDGE DAKSEATKSC GKINFSLRYD YETETLIVRI LKAFDLPAKD FCGSSDPYVK IYLLPDRKCK LQTRVHRKTL NPTFDENFHF PVPYEELADR KLHLSVFDFD RFSRHDMIGE VILDNLFEAS DLSRETSIWK DIQYATSESV DLGEIMFSLC YLPTAGRLTL TVIKCRNLKA MDITGYSDPY VKVSLLCDGR RLKKKKTTIK KNTLNPVYNE AIIFDIPPEN MDQVSLLISV MDYDRVGHNE IIGVCRVGIT AEGLGRDHWN EMLAYPRKPI AHWHSLVEVK KSFKEGNPRL