SYT4_HUMAN » Synaptotagmin-4

SYT4_HUMAN » Synaptotagmin-4
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Topology in Vesicle membrane
Topologyvesicle lumenal side
cytoplasmic side
SYT4_HUMAN » Synaptotagmin-4 » Synaptotagmin IV;SytIV;
Hydrophobic Thickness 30.8 ± 5.0 Å
Tilt Angle 39 ± 7°
ΔGtransfer -22.0 kcal/mol
ΔGfold -16.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 13-37 (13-43)
Pathways none
PDB 1ugk (154-278)
OPM 1ugk
Complexes none
Interactions

STX1A, Complex: STX1A:SYT4, PubMed

STX2, Complex: SYT4:STX2, PubMed

STX3, Complex: SYT4:STX3, PubMed

STX4, Complex: SYT4:STX4, PubMed

SYT1, Complex: SYT4:SYT1, PubMed

Domains

AA: 168-274, PDBID: 1UGK, Subunit A, Seq Identity:100%, C2 domain

AA: 302-408, PDBID: 1W15, Subunit A, Seq Identity:94%, C2 domain

UniProt annotation for SYT4_HUMAN » Synaptotagmin-4
FUNCTION: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.

TISSUE SPECIFICITY: Expressed in brain. Within brain, expression is highest in hippocampus, with substantial levels also detected in amygdala and thalamus.

UniProt features for SYT4_HUMAN » Synaptotagmin-4
CHAIN 1 425 Synaptotagmin-4.
DOMAIN 155 258 C2 1.
DOMAIN 289 392 C2 2.
REGION 147 297 Phospholipid binding (Probable).
Amino Acid Sequence for SYT4_HUMAN » Synaptotagmin-4
MAPITTSREE FDEIPTVVGI FSAFGLVFTV SLFAWICCQR KSSKSNKTPP YKFVHVLKGV DIYPENLNSK KKFGADDKNE VKNKPAVPKN SLHLDLEKRD LNGNFPKTNL KPGSPSDLEN ATPKLFLEGE KESVSPESLK SSTSLTSEEK QEKLGTLFFS LEYNFERKAF VVNIKEARGL PAMDEQSMTS DPYIKMTILP EKKHKVKTRV LRKTLDPAFD ETFTFYGIPY TQIQELALHF TILSFDRFSR DDIIGEVLIP LSGIELSEGK MLMNREIIKR NVRKSSGRGE LLISLCYQST TNTLTVVVLK ARHLPKSDVS GLSDPYVKVN LYHAKKRISK KKTHVKKCTP NAVFNELFVF DIPCEGLEDI SVEFLVLDSE RGSRNEVIGQ LVLGAAAEGT GGEHWKEICD YPRRQIAKWH VLCDG