SYT3_HUMAN » Synaptotagmin-3

SYT3_HUMAN » Synaptotagmin-3
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Topology in Vesicle membrane
Topologyvesicle lumenal side
cytoplasmic side
SYT3_HUMAN » Synaptotagmin-3 » Synaptotagmin III;SytIII;
Hydrophobic Thickness 30.8 ± 3.0 Å
Tilt Angle 41 ± 1°
ΔGtransfer -21.7 kcal/mol
ΔGfold -15.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 49-74 (49-76)
Pathways none
PDB none
OPM 3hn8 (RAT)
Complexes none
Interactions

SYT5, Complex: SYT5:SYT3, PubMed

Domains

AA: 314-421, PDBID: 1DQV, Subunit A, Seq Identity:99%, C2 domain

AA: 446-553, PDBID: 1DQV, Subunit A, Seq Identity:98%, C2 domain

UniProt annotation for SYT3_HUMAN » Synaptotagmin-3
FUNCTION: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.

SUBUNIT: Homodimer. Can also form heterodimers with SYT6 (By similarity).

DOMAIN: The first C2 domain mediates Ca(2+)-dependent phospholipid binding.

UniProt features for SYT3_HUMAN » Synaptotagmin-3
CHAIN 1 590 Synaptotagmin-3.
DOMAIN 301 402 C2 1.
DOMAIN 433 536 C2 2.
Amino Acid Sequence for SYT3_HUMAN » Synaptotagmin-3
MSGDYEDDLC RRALILVSDL CARVRDADTN DRCQEFNDRI RGYPRGPDAD ISVSLLSVIV TFCGIVLLGV SLFVSWKLCW VPWRDKGGSA VGGGPLRKDL GPGVGLAGLV GGGGHHLAAG LGGHPLLGGP HHHAHAAHHP PFAELLEPGS LGGSDTPEPS YLDMDSYPEA AAAAVAAGVK PSQTSPELPS EGGAGSGLLL LPPSGGGLPS AQSHQQVTSL APTTRYPALP RPLTQQTLTS QPDPSSEERP PALPLPLPGG EEKAKLIGQI KPELYQGTGP GGRRSGGGPG SGEAGTGAPC GRISFALRYL YGSDQLVVRI LQALDLPAKD SNGFSDPYVK IYLLPDRKKK FQTKVHRKTL NPVFNETFQF SVPLAELAQR KLHFSVYDFD RFSRHDLIGQ VVLDNLLELA EQPPDRPLWR DIVEGGSEKA DLGELNFSLC YLPTAGRLTV TIIKASNLKA MDLTGFSDPY VKASLISEGR RLKKRKTSIK KNTLNPTYNE ALVFDVAPES VENVGLSIAV VDYDCIGHNE VIGVCRVGPD AADPHGREHW AEMLANPRKP VEHWHQLVEE KTVTSFTKGS KGLSEKENSE