SYT2_HUMAN » Synaptotagmin-2

SYT2_HUMAN » Synaptotagmin-2
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Topology in Vesicle membrane
Topologyvesicle lumenal side
cytoplasmic side
SYT2_HUMAN » Synaptotagmin-2 » Synaptotagmin II;SytII;
Hydrophobic Thickness 31.6 ± 2.2 Å
Tilt Angle 0 ± 2°
ΔGtransfer -36.4 kcal/mol
ΔGfold -18.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome, HMDB
Topology Out
TM Segments 62-83 (62-92)
Pathways

Neuronal System (Reactome)

PDB none
OPM none
Complexes none
Interactions

TGON2, Complex: TGON2:SYT2, PubMed

Domains

AA: 154-260, PDBID: 1BYN, Subunit A, Seq Identity:87%, C2 domain

AA: 285-391, PDBID: 1K5W, Subunit A, Seq Identity:87%, C2 domain

UniProt annotation for SYT2_HUMAN » Synaptotagmin-2
FUNCTION: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (By similarity).

SUBUNIT: Homotetramer (Probable). Interacts with stonin 2 (By similarity). Interacts with SCAMP5.

DOMAIN: The first C2 domain mediates Ca(2+)-dependent phospholipid binding.

DOMAIN: The second C2 domain mediates interaction with Stonin 2.

DISEASE: Myasthenic syndrome, presynaptic, congenital, with or without motor neuropathy (MYSPC) OMIM: An autosomal dominant presynaptic neuromuscular junction disorder resembling Lambert-Eaton myasthenic syndrome. Affected individuals show foot deformities, a variable degree of proximal and distal limb weakness, muscle fatigue that improves with rest, mild gait difficulties, and reduced or absent deep tendon reflexes. mutations affecting the gene represented in this entry.

UniProt features for SYT2_HUMAN » Synaptotagmin-2
CHAIN 1 419 Synaptotagmin-2.
DOMAIN 141 242 C2 1.
DOMAIN 272 375 C2 2.
REGION 133 379 Phospholipid binding (By similarity).
Amino Acid Sequence for SYT2_HUMAN » Synaptotagmin-2
MRNIFKRNQE PIVAPATTTA TMPIGPVDNS TESGGAGESQ EDMFAKLKEK LFNEINKIPL PPWALIAIAV VAGLLLLTCC FCICKKCCCK KKKNKKEKGK GMKNAMNMKD MKGGQDDDDA ETGLTEGEGE GEEEKEPENL GKLQFSLDYD FQANQLTVGV LQAAELPALD MGGTSDPYVK VFLLPDKKKK YETKVHRKTL NPAFNETFTF KVPYQELGGK TLVMAIYDFD RFSKHDIIGE VKVPMNTVDL GQPIEEWRDL QGGEKEEPEK LGDICTSLRY VPTAGKLTVC ILEAKNLKKM DVGGLSDPYV KIHLMQNGKR LKKKKTTVKK KTLNPYFNES FSFEIPFEQI QKVQVVVTVL DYDKLGKNEA IGKIFVGSNA TGTELRHWSD MLANPRRPIA QWHSLKPEEE VDALLGKNK