SYT1_ARATH » Synaptotagmin-1

SYT1_ARATH » Synaptotagmin-1
Magnify SYT1_ARATH » Synaptotagmin-1Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SYT1_ARATH » Synaptotagmin-1 » NTMC2T1.1;Synaptotagmin A;
Hydrophobic Thickness 36.0 ± 1.2 Å
Tilt Angle 1 ± 0°
ΔGtransfer -37.2 kcal/mol
ΔGfold -13.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 3-31 (3-32)
Pathways

Synaptic vesicle cycle (KEGG)

PDB none
OPM 1byn (RAT), 1rsy (RAT), 1uov (RAT), 2r83 (HUMAN), 3f00 (HUMAN), 4v11 (HUMAN)
Complexes none
Interactions none
Domains

AA: 67-249, PDBID: 4P42, Subunit B, Seq Identity:24%, Synaptotagmin-like mitochondrial-lipid-binding domain

AA: 260-364, PDBID: 2EP6, Subunit A, Seq Identity:35%, C2 domain

AA: 420-523, PDBID: 2B3R, Subunit B, Seq Identity:26%, C2 domain

UniProt annotation for SYT1_ARATH » Synaptotagmin-1
FUNCTION: Plays an important role in maintaining plasma membrane integrity during freezing and osmotic stresses. May function in membrane resealing during calcium-dependent freezing tolerance. May regulate endocytosis and endosome recycling at the plasma membrane and cell-to-cell trafficking of cabbage leaf curl virus (CaLCuV) and tobacco mosaic virus (TMV) movement proteins via plasmodesmata.

SUBUNIT: Interacts with cabbage leaf curl virus (CaLCuV) BC1 protein and tobacco mosaic virus (TMV) MP protein.

TISSUE SPECIFICITY: Expressed in roots, shoots, rosette and cauline leaves, inflorescences, and siliques. In roots, expressed in vascular bundle, epidermis, the differential zone of the tips of root hairs, and the quiescent center and columella of root tips.

MISCELLANEOUS: Phospholipid binding to the first C2 domain is calcium-depedent, but binding to the second C2 domain is calcium- independent.

UniProt features for SYT1_ARATH » Synaptotagmin-1
CHAIN 1 541 Synaptotagmin-1.
DOMAIN 247 346 C2 1.
DOMAIN 407 505 C2 2.
REGION 227 509 Phospholipid binding (By similarity).
Amino Acid Sequence for SYT1_ARATH » Synaptotagmin-1
MGFFSTILGF CGFGVGISLG LVIGYVLFVY LLPNDVKDPE IRSIADQDPK AMLRMLPEIP LWVKNPDFDR VDWINRFLEY MWPYLDKAIC KTAKNIAKPI IEEQIPKYKI DSVEFETLTL GSLPPTFQGM KVYLTDEKEL IMEPCLKWAA NPNILVAIKA FGLKATVQVV DLQVFAQPRI TLKPLVPSFP CFANIYVSLM EKPHVDFGLK LGGADLMSIP GLYRFVQEQI KDQVANMYLW PKTLVVPILD PAKAFRRPVG IVHVKVVRAV GLRKKDLMGG ADPFVKIKLS EDKIPSKKTT VKHKNLNPEW NEEFKFSVRD PQTQVLEFSV YDWEQVGNPE KMGMNVLALK EMVPDEHKAF TLELRKTLDG GEDGQPPDKY RGKLEVELLY KPFTEEEMPK GFEETQAVQK APEGTPAAGG MLVVIVHSAE DVEGKHHTNP YVRIYFKGEE RKTKHVKKNR DPRWNEEFTF MLEEPPVREK LHVEVLSTSS RIGLLHPKET LGYVDIPVVD VVNNKRMNQK FHLIDSKNGK IQIELEWRTA S